FIORANI, PAOLA

FIORANI, PAOLA  

FARMACOLOGIA TRASLAZIONALE - IFT  

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Titolo Data di pubblicazione Autore(i) File
Cow Milk Extracellular Vesicle Effects on an In Vitro Model of Intestinal Inflammation 1-gen-2022 Mecocci, S.; Ottaviani, A.; Razzuoli, E.; Fiorani, P.; Pietrucci, D.; De Ciucis, C. G.; Giudici, S. D.; Franzoni, G.; Chillemi, G.; Cappelli, K.
Dimethylmyricacene: An In Vitro and In Silico Study of a Semisynthetic Non-Camptothecin Derivative Compound, Targeting Human DNA Topoisomerase 1B 1-gen-2022 Ottaviani, A.; Iacovelli, F.; Welsch, J.; Morozzo della Rocca, B.; Desideri, A.; Falconi, M.; Calcul, L.; Baker, B. J.; Fiorani, P.
From Antarctica to cancer research: a novel human DNA topoisomerase 1B inhibitor from Antarctic sponge Dendrilla antarctica 1-gen-2022 Ottaviani, A.; Welsch, J.; Agama, K.; Pommier, Y.; Desideri, A.; Baker, B. J.; Fiorani, P.
In vitro and in silico characterization of an antimalarial compound with antitumor activity targeting human DNA topoisomerase IB 1-gen-2021 Soren, B. C. ; Dasari J. B. ; Ottaviani A. ; Messina B. ; Andreotti G. ; Romeo A. ; Iacovelli F. ; Falconi M. ; Desideri A.; Fiorani, P.
Natural compounds as therapeutic agents: The case of human topoisomerase ib 1-gen-2021 Ottaviani, A.; Iacovelli, F.; Fiorani, P.; Desideri, A.
Swapping of The N-Terminal Domain of Human Topoisomerase 1B with the Corresponding Plasmodium Falciparum Counterpart Strongly Impairs Enzyme Activity 1-gen-2020 Dasari Jagadish, Babu; Soren Bini, Chhetri; Ottaviani, Alessio; Tesauro, Cinzia; Marino, Simona; Messina, Beatrice; Fiorani, Paola
Topoisomerase IB: a relaxing enzyme for stressed DNA 1-gen-2020 Chhetri Soren, Bini; Babu Dasari, Jagadish; Ottaviani, Alessio; Iacovelli, Federico; Fiorani, Paola
The human DNA topoisomerase I mutant Gly717Asp: Higher religation rate is not always associated with camptothecin resistance 1-gen-2019 Wang, Zhenxing; D'Annessa, Ilda; Tesauro, Cinzia; Ottaviani, Alessio; Soren Bini, Chhetri; Dasari Jagadish, Babu; Messina, Beatrice; Thareparambil, Anil; Fiorani, Paola
Real-time analysis of cleavage and religation activity of human topoisomerase 1 based on ternary fluorescence resonance energy transfer DNA substrate 1-gen-2018 Wang, Zhenxing; Ouyang, Hui; Tesauro, Cinzia; Ottaviani, Alessio; He, Yong; Fiorani, Paola; Xie, Hui; Desideri, Alessandro; Fu, Zhifeng
Mutation of Gly717Phe in human topoisomerase 1B has an effect on enzymatic function, reactivity to the camptothecin anticancer drug and on the linker domain orientation 1-gen-2015 Wang, Z; D'Annessa, I; Tesauro, C; Croce, S; Ottaviani, A; Fiorani, P; Desideri, A
Real-Time Label-Free Direct Electronic Monitoring of Topoisomerase Enzyme Binding Kinetics on Graphene 1-gen-2015 Zuccaro, Laura; Tesauro, Cinzia; Kurkina, Tetiana; Fiorani, Paola; Yu Hak, Ki; Knudsen Birgitta, R; Kern, Klaus; Desideri, Alessandro; Balasubramanian, Kannan
Mutations of human DNA topoisomerase I at poly (ADP-ribose) binding sites: Modulation of camptothecin activity by ADP-ribose polymers 1-gen-2014 Tesauro, C; Graziani, G; Arno, B; Zuccaro, L; Muzi, A; D'Annessa, I; Santori, E; Tentori, L; Leonetti, C; Fiorani, P; Desideri, A
A small organic compound enhances the religation reaction of human topoisomerase I and identifies crucial elements for the religation mechanism 1-gen-2013 Arno, Barbara; Coletta, Andrea; Tesauro, Cinzia; Zuccaro, Laura; Fiorani, Paola; Lentini, Sara; Galloni, Pierluca; Conte, Valeria; Floris, Barbara; Desideri, Alessandro
Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico 1-gen-2013 Tesauro, C; Morozzo della Rocca, B; Ottaviani, A; Coletta, A; Zuccaro, L; Arno, B; D'Annessa, I; Fiorani, P; Desideri, A
Replacement of the Human Topoisomerase Linker Domain with the Plasmodial Counterpart Renders the Enzyme Camptothecin Resistant 1-gen-2013 Arno, B; D'Annessa, I; Tesauro, C; Zuccaro, L; Ottaviani, A; Knudsen, B; Fiorani, P; Desideri, A
The human topoisomerase 1B Arg634Ala mutation results in camptothecin resistance and loss of inter-domain motion correlation 1-gen-2013 D'Annessa, Ilda; Tesauro, Cinzia; Wang, Zhenxing; Arno, Barbara; Zuccaro, Laura; Fiorani, Paola; Desideri, Alessandro
Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing plasmodium parasites based on enzyme activity measurement 1-gen-2012 Juul, S; Nielsen, Cjf; Labouriau, R; Roy, A; Tesauro, C; Jensen, Pw; Harmsen, C; Kristoffersen, El; Chiu, Yl; Frohlich, R; Fiorani, P; Coxsingh, J; Tordrup, D; Koch, J; Bienvenu, Al; Desideri, A; Picot, S; Petersen, E; Leong, Kw; Ho, Yp; Stougaard, M; Knudsen, Br
Interaction between natural compounds and human topoisomerase i 1-gen-2012 Castelli, S; Coletta, A; D'Annessa, I; Fiorani, P; Tesauro, C; Desideri, A
Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin. 1-gen-2012 D'Annessa, Ilda; Tesauro, Cinzia; Fiorani, Paola; Chillemi, Giovanni; Castelli, Silvia; Vassallo, Oscar; Capranico, Giovanni; Desideri, Alessandro
Specific detection of topoisomerase I from the malaria causing P. falciparum parasite using isothermal rolling circle amplification. 1-gen-2012 Tesauro, C; Juul, S; Arno, B; Nielsen, Cj; Fiorani, P; Frohlich, Rf; Andersen, Ff; Desideri, A; Stougaard, M; Petersen, E; Knudsen, Br