D'URSI, PASQUALINA
D'URSI, PASQUALINA
Istituto di Tecnologie Biomediche - ITB
Alzheimer's Disease Etiology Hypotheses and Therapeutic Strategies: A Perspective
2025 Scarano, Naomi; Musumeci, Francesca; Casini, Beatrice; Brullo, Chiara; D'Ursi, Pasqualina; Fossa, Paola; Schenone, Silvia; Cichero, Elena
Characterisation of the Binding Pocket and Drug Repositioning to Inhibit the Interaction Between the RBD Spike Protein of SARS-CoV-2 Omicron BA.1 and Integrins
2025 Casini, B.; Trombetti, G. A.; Fossa, P.; Zheng, Y.; Bugatti, A.; Caruso, A.; Caccuri, F.; D'Ursi, Pasqualina
Deciphering the landscape of allosteric glutaminase 1 inhibitors as anticancer agents
2025 Vagaggini, C.; D'Ursi, P.; Poggialini, F.; Fossa, P.; Francesconi, V.; Trombetti, G.; Orro, A.; Dreassi, E.; Schenone, S.; Tonelli, M.; Carbone, A.
Fragment Based Design of GLS1 Allosteric Inhibitors for Cancer Therapy
2025 Allahi, S.; Trombetti, G. A.; Poggialini, F.; Vagaggini, C.; Dreassi, E.; Tonelli, M.; Schenone, S.; Fossa, P.; D'Ursi, Pasqualina; Carbone, A.
Molecular Mechanisms Involved in the B Cell Growth and Clonogenic Activity of HIV-1 Matrix Protein p17 Variants
2024 D'Ursi, Pasqualina; Rondina, Alessandro; Zani, Alberto; Uggeri, Matteo; Messali, Serena; Caruso, Arnaldo; Caccuri, Francesca
An innovative strategy to investigate microbial protein modifications in a reliable fast and sensitive way: A therapy oriented proof of concept based on UV-C irradiation of SARS-CoV-2 spike protein
2023 Strizzi, Sergio; Bernardo, Letizia; D’Ursi, Pasqualina; Urbinati, Chiara; Bianco, Andrea; Limanaqi, Fiona; Manconi, Andrea; Milanesi, Maria; Macchi, Alberto; DI SILVESTRE, Dario; Cavalleri, Adalberto; Pareschi, Giovanni; Rusnati, Marco; Clerici, Mario; Mauri, Pierluigi; Biasin, Mara
Germline NUP98 Variants in Two Siblings with a Rothmund–Thomson-Like Spectrum: Protein Functional Changes Predicted by Molecular Modeling
2023 Colombo, E. A.; Valiante, M.; Uggeri, M.; Orro, A.; Majore, S.; Grammatico, P.; Gentilini, D.; Finelli, P.; Gervasini, C.; D'Ursi, P.; Larizza, L.
Implementation of a drug discovery pipeline on the D4Science platform
2023 Orro, A; D'Ursi, P; Fossa, P; Candela, L; Panichi, G
Competition for dominance within replicating quasispecies during prolonged SARS-CoV-2 infection in an immunocompromised host
2022 Caccuri, F; Messali, S; Bortolotti, D; Di Silvestre, D; De Palma, A; Cattaneo, C; Bertelli, A; Zani, A; Milanesi, M; Giovanetti, M; Campisi, G; Gentili, V; Bugatti, A; Filippini, F; Scaltriti, E; Pongolini, S; Tucci, A; Fiorentini, S; D'Ursi, P; Ciccozzi, M; Mauri, P; Rizzo, R; Caruso, A
Virtual Drug Repositioning as a Tool to Identify Natural Small Molecules That Synergize with Lumacaftor in F508del-CFTR Binding and Rescuing
2022 Fossa, P.; Uggeri, M.; Orro, A.; Urbinati, C.; Rondina, A.; Milanesi, M.; Pedemonte, N.; Pesce, E.; Padoan, R.; Ford, R. C.; Meng, X.; Rusnati, M.; D'Ursi, P.
A boron delivery antibody (BDA) with boronated specific residues: New perspectives in boron neutron capture therapy from an in silico investigation
2021 Rondina, A.; Fossa, P.; Orro, A.; Milanesi, L.; De Palma, A.; Perico, D.; Mauri, P. L.; D'Ursi, P.
Evolution toward beta common chain receptor usage links the matrix proteins of HIV-1 and its ancestors to human erythropoietin
2021 Caccuri, F.; D'Ursi, P.; Uggeri, M.; Bugatti, A.; Mazzuca, P.; Zani, A.; Filippini, F.; Salmona, M.; Ribatti, D.; Slevin, M.; Orro, A.; Lu, W.; Lio, P.; Gallo, R. C.; Caruso, A.
In silico drug repositioning on F508del-CFTR: A proof-of-concept study on the AIFA library
2021 Orro, A.; Uggeri, M.; Rusnati, M.; Urbinati, C.; Pedemonte, N.; Pesce, E.; Moscatelli, M.; Padoan, R.; Cichero, E.; Fossa, P.; D'Ursi, P.
Role of Q675H Mutation in Improving SARS-CoV-2 Spike Interaction with the Furin Binding Pocket
2021 Bertelli, Anna; D'Ursi, Pasqualina; Campisi, Giovanni; Messali, Serena; Milanesi, Maria; Giovanetti, Marta; Ciccozzi, Massimo; Caccuri, Francesca; Caruso, Arnaldo
B-cell clonogenic activity of HIV-1 p17 variants is driven by PAR1-mediated EGF transactivation
2020 Giagulli, C; Caccuri, F; Zorzan, S; Bugatti, A; Zani, A; Filippini, F; Manocha, E; D'Ursi, P; Orro, A; Dolcetti, R; Caruso, A
Recent Strategic Advances in CFTR Drug Discovery: An Overview
2020 Rusnati, Marco; D'Ursi, Pasqualina; Pedemonte, Nicoletta; Urbinati, Chiara; Ford Robert, C; Cichero, Elena; Uggeri, Matteo; Orro, Alessandro; Fossa, Paola
Blockade of IGF2R improves muscle regeneration and ameliorates Duchenne muscular dystrophy
2019 Bella, Pamela; Farini, Andrea; Banfi, Stefania; Parolini, Daniele; Tonna, Noemi; Meregalli, Mirella; Belicchi, Marzia; Erratico, Silvia; D'Ursi, Pasqualina; Bianco, Fabio; Legato, Mariella; Ruocco, Chiara; Sitzia, Clementina; Sangiorgi, Simone; Villa, Chiara; D'Antona, Giuseppe; Milanesi, Luciano; Nisoli, Enzo; Mauri, Pierluigi; Torrente, Yvan
Exploitation of a novel biosensor based on the full-length human F508de1-CFTR with computational studies, biochemical and biological assays for the characterization of a new Lumacaftor/Tezacaftor analogue
2019 D'Ursi, P; Uggeri, M; Urbinati, C; Millo, E; Paiardi, G; Milanesi, L; Ford, R C; Clews, J; Meng, X; Bergese, P; Ridolfi, A; Pedemonte, N; Fossa, P; Orro, A; Rusnati, M
Characterization of multi-locus imprinting disturbances and underlying genetic defects in patients with chromosome 11p15.5 related imprinting disorders
2018 Fontana, L.; Bedeschi, M. F.; Maitz, S.; Cereda, A.; Fare, C.; Motta, S.; Seresini, A.; D'Ursi, P.; Orro, A.; Pecile, V.; Calvello, M.; Selicorni, A.; Lalatta, F.; Milani, D.; Sirchia, S. M.; Miozzo, M.; Tabano, S.
Characterization of multi-locus imprinting disturbances and underlying genetic defects in patients with chromosome 11p15.5 related imprinting disorders
2018 Fontana L; Bedeschi MF; Maitz S; Cereda A; Faré C; Motta S; Seresini A; D'Ursi P; Orro A; Pecile V; Calvello M; Selicorni A; Lalatta F; Milani D; Sirchia SM; Miozzo M; Tabano S.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Alzheimer's Disease Etiology Hypotheses and Therapeutic Strategies: A Perspective | 1-gen-2025 | Scarano, Naomi; Musumeci, Francesca; Casini, Beatrice; Brullo, Chiara; D'Ursi, Pasqualina; Fossa, Paola; Schenone, Silvia; Cichero, Elena | |
| Characterisation of the Binding Pocket and Drug Repositioning to Inhibit the Interaction Between the RBD Spike Protein of SARS-CoV-2 Omicron BA.1 and Integrins | 1-gen-2025 | Casini, B.; Trombetti, G. A.; Fossa, P.; Zheng, Y.; Bugatti, A.; Caruso, A.; Caccuri, F.; D'Ursi, Pasqualina | |
| Deciphering the landscape of allosteric glutaminase 1 inhibitors as anticancer agents | 1-gen-2025 | Vagaggini, C.; D'Ursi, P.; Poggialini, F.; Fossa, P.; Francesconi, V.; Trombetti, G.; Orro, A.; Dreassi, E.; Schenone, S.; Tonelli, M.; Carbone, A. | |
| Fragment Based Design of GLS1 Allosteric Inhibitors for Cancer Therapy | 1-gen-2025 | Allahi, S.; Trombetti, G. A.; Poggialini, F.; Vagaggini, C.; Dreassi, E.; Tonelli, M.; Schenone, S.; Fossa, P.; D'Ursi, Pasqualina; Carbone, A. | |
| Molecular Mechanisms Involved in the B Cell Growth and Clonogenic Activity of HIV-1 Matrix Protein p17 Variants | 1-gen-2024 | D'Ursi, Pasqualina; Rondina, Alessandro; Zani, Alberto; Uggeri, Matteo; Messali, Serena; Caruso, Arnaldo; Caccuri, Francesca | |
| An innovative strategy to investigate microbial protein modifications in a reliable fast and sensitive way: A therapy oriented proof of concept based on UV-C irradiation of SARS-CoV-2 spike protein | 1-gen-2023 | Strizzi, Sergio; Bernardo, Letizia; D’Ursi, Pasqualina; Urbinati, Chiara; Bianco, Andrea; Limanaqi, Fiona; Manconi, Andrea; Milanesi, Maria; Macchi, Alberto; DI SILVESTRE, Dario; Cavalleri, Adalberto; Pareschi, Giovanni; Rusnati, Marco; Clerici, Mario; Mauri, Pierluigi; Biasin, Mara | |
| Germline NUP98 Variants in Two Siblings with a Rothmund–Thomson-Like Spectrum: Protein Functional Changes Predicted by Molecular Modeling | 1-gen-2023 | Colombo, E. A.; Valiante, M.; Uggeri, M.; Orro, A.; Majore, S.; Grammatico, P.; Gentilini, D.; Finelli, P.; Gervasini, C.; D'Ursi, P.; Larizza, L. | |
| Implementation of a drug discovery pipeline on the D4Science platform | 1-gen-2023 | Orro, A; D'Ursi, P; Fossa, P; Candela, L; Panichi, G | |
| Competition for dominance within replicating quasispecies during prolonged SARS-CoV-2 infection in an immunocompromised host | 1-gen-2022 | Caccuri, F; Messali, S; Bortolotti, D; Di Silvestre, D; De Palma, A; Cattaneo, C; Bertelli, A; Zani, A; Milanesi, M; Giovanetti, M; Campisi, G; Gentili, V; Bugatti, A; Filippini, F; Scaltriti, E; Pongolini, S; Tucci, A; Fiorentini, S; D'Ursi, P; Ciccozzi, M; Mauri, P; Rizzo, R; Caruso, A | |
| Virtual Drug Repositioning as a Tool to Identify Natural Small Molecules That Synergize with Lumacaftor in F508del-CFTR Binding and Rescuing | 1-gen-2022 | Fossa, P.; Uggeri, M.; Orro, A.; Urbinati, C.; Rondina, A.; Milanesi, M.; Pedemonte, N.; Pesce, E.; Padoan, R.; Ford, R. C.; Meng, X.; Rusnati, M.; D'Ursi, P. | |
| A boron delivery antibody (BDA) with boronated specific residues: New perspectives in boron neutron capture therapy from an in silico investigation | 1-gen-2021 | Rondina, A.; Fossa, P.; Orro, A.; Milanesi, L.; De Palma, A.; Perico, D.; Mauri, P. L.; D'Ursi, P. | |
| Evolution toward beta common chain receptor usage links the matrix proteins of HIV-1 and its ancestors to human erythropoietin | 1-gen-2021 | Caccuri, F.; D'Ursi, P.; Uggeri, M.; Bugatti, A.; Mazzuca, P.; Zani, A.; Filippini, F.; Salmona, M.; Ribatti, D.; Slevin, M.; Orro, A.; Lu, W.; Lio, P.; Gallo, R. C.; Caruso, A. | |
| In silico drug repositioning on F508del-CFTR: A proof-of-concept study on the AIFA library | 1-gen-2021 | Orro, A.; Uggeri, M.; Rusnati, M.; Urbinati, C.; Pedemonte, N.; Pesce, E.; Moscatelli, M.; Padoan, R.; Cichero, E.; Fossa, P.; D'Ursi, P. | |
| Role of Q675H Mutation in Improving SARS-CoV-2 Spike Interaction with the Furin Binding Pocket | 1-gen-2021 | Bertelli, Anna; D'Ursi, Pasqualina; Campisi, Giovanni; Messali, Serena; Milanesi, Maria; Giovanetti, Marta; Ciccozzi, Massimo; Caccuri, Francesca; Caruso, Arnaldo | |
| B-cell clonogenic activity of HIV-1 p17 variants is driven by PAR1-mediated EGF transactivation | 1-gen-2020 | Giagulli, C; Caccuri, F; Zorzan, S; Bugatti, A; Zani, A; Filippini, F; Manocha, E; D'Ursi, P; Orro, A; Dolcetti, R; Caruso, A | |
| Recent Strategic Advances in CFTR Drug Discovery: An Overview | 1-gen-2020 | Rusnati, Marco; D'Ursi, Pasqualina; Pedemonte, Nicoletta; Urbinati, Chiara; Ford Robert, C; Cichero, Elena; Uggeri, Matteo; Orro, Alessandro; Fossa, Paola | |
| Blockade of IGF2R improves muscle regeneration and ameliorates Duchenne muscular dystrophy | 1-gen-2019 | Bella, Pamela; Farini, Andrea; Banfi, Stefania; Parolini, Daniele; Tonna, Noemi; Meregalli, Mirella; Belicchi, Marzia; Erratico, Silvia; D'Ursi, Pasqualina; Bianco, Fabio; Legato, Mariella; Ruocco, Chiara; Sitzia, Clementina; Sangiorgi, Simone; Villa, Chiara; D'Antona, Giuseppe; Milanesi, Luciano; Nisoli, Enzo; Mauri, Pierluigi; Torrente, Yvan | |
| Exploitation of a novel biosensor based on the full-length human F508de1-CFTR with computational studies, biochemical and biological assays for the characterization of a new Lumacaftor/Tezacaftor analogue | 1-gen-2019 | D'Ursi, P; Uggeri, M; Urbinati, C; Millo, E; Paiardi, G; Milanesi, L; Ford, R C; Clews, J; Meng, X; Bergese, P; Ridolfi, A; Pedemonte, N; Fossa, P; Orro, A; Rusnati, M | |
| Characterization of multi-locus imprinting disturbances and underlying genetic defects in patients with chromosome 11p15.5 related imprinting disorders | 1-gen-2018 | Fontana, L.; Bedeschi, M. F.; Maitz, S.; Cereda, A.; Fare, C.; Motta, S.; Seresini, A.; D'Ursi, P.; Orro, A.; Pecile, V.; Calvello, M.; Selicorni, A.; Lalatta, F.; Milani, D.; Sirchia, S. M.; Miozzo, M.; Tabano, S. | |
| Characterization of multi-locus imprinting disturbances and underlying genetic defects in patients with chromosome 11p15.5 related imprinting disorders | 1-gen-2018 | Fontana L; Bedeschi MF; Maitz S; Cereda A; Faré C; Motta S; Seresini A; D'Ursi P; Orro A; Pecile V; Calvello M; Selicorni A; Lalatta F; Milani D; Sirchia SM; Miozzo M; Tabano S. |