PESARESI, ALESSANDRO
PESARESI, ALESSANDRO
Istituto di Cristallografia - IC
Disentangling the formation, mechanism, and evolvement of the covalent methanesulfonyl fluoride acetylcholinesterase adduct: Insights into an aged‐like inactive complex susceptible to reactivation by a combination of nucleophiles
2024 Stojan, Jure; Pesaresi, Alessandro; Meden, Anže; Lamba, Doriano
Mixed and non-competitive enzyme inhibition: underlying mechanisms andmechanistic irrelevance of the formal two-site model
2023 Pesaresi, Alessandro
Nonallosteric activation of posttranslational modification enzymes by active site-directed inhibitors
2023 Pesaresi, Alessandro
Kinetic and structural studies on the inhibition of acetylcholinesterase and butyrylcholinesterase by a series of multitarget-directed galantamine-peptide derivatives
2022 Pesaresi, A; Lamba, D; Vezenkov, L; Tsekova, D; Lozanov, V
Kinetic Modeling of Time-Dependent Enzyme Inhibition by Pre-Steady-State Analysis of Progress Curves: The Case Study of the Anti-Alzheimer's Drug Galantamine
2022 Lamba, Doriano; Pesaresi, Alessandro
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
2019 Chalupova K.; Korabecny J.; Bartolini M.; Monti B.; Lamba D.; Caliandro R.; Pesaresi A.; Brazzolotto X.; Gastellier A.J.; Nachon F.; Pejchal J.; Jarosova M.; Hepnarova V.; Jun D.; Hrabinova M.; Dolezal R.; Zdarova Karasova J.; Mzik M.; Kristofikova Z.; Misik J.; Muckova L.; Jost P.; Soukup O.; Benkova M.; Setnicka V.; Habartova L.; Chvojkova M.; Kleteckova L.; Vales K.; Mezeiova E.; Uliassi E.; Valis M.; Nepovimova E.; Bolognesi M.L.; Kuca K.
"Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid Analogues"
2018 Caliandro R.; Pesaresi A.; Cariati L. Procopio A.; Oliverio M.; Lamba D.
Polypharmacology-based strategies in Alzheimer's disease: the Yin and the Yang of acetylcholinesterase inhibition
2017 Pesaresi, A; Lamba, D
Polypharmacology-based strategies in Alzheimer's disease: the Yin and the Yang of acetylcholinesterase inhibition
2017 Pesaresi, A; Lamba, D
Polypharmacology-based strategies in Alzheimer's disease: the Yin and the Yang of acetylcholinesterase inhibition
2017 Lamba, D; Bartolini, M; Rosini, M; Bolognesi, Ml; Korabecny, J; Zha, X; Pesaresi, A
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease:Design, Synthesis, Biological Evaluation and X-ray Crystallography
2016 Zha, Xiaoming; Lamba, Doriano; Zhanga, Lili; A, Yinghan Lou; D, ; Xua, Changxu; Dikanga, ; Chen, Li; Xu, Yungen; Zhang, Luyong; De Simone, Angela; B, Sarah Samez; F, ; Pesaresi, Alessandro; Stojan, Jure; G Lopez, Manuela; Egea, Javier; Vincenzaandrisano, ; Bartolini, Manuela
Polypharmacology-based strategies in Alzheimer's disease: the Yin and the Yan of Acetylcholinesterase inhibition
2016 Pesaresi A.; Lamba D.
Multi-Target-Directed Ligands in Alzheimer's Disease Treatment
2015 Pesaresi, A; Samez, S; Bartolini, M; Stojan, J; Garcia, Ge; Zha, X; Bolognesi, Ml; Lamba, D
Multitarget drug design strategy: tacrine-quinone hybrids designed to block amyloid-beta aggregation and to exert anticholinesterase and antioxidant effects
2015 A. Pesaresi ; S. Samez; E. Nepovimova;; E. Uliassi; J. Korabecny; L.E. PeñaAltamira; G.E. Garcia; M. Bartolini; V. Andrisano; C. Bergamini; R. Fato; M. Roberti; K. Kuca; B. Monti;M.L. Bolognesi;D. Lamba
MULTI-TARGET-DIRECTED LIGANDS IN ALZHEIMER'S DISEASE TREATMENT
2014 Samez, Sarah; Pesaresi, Alessandro; Bartolini, Manuela; Zha, Xiaoming; Laura Bolognesi, Maria; Lamba, Doriano
Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects
2014 Nepovímová, Eugenie; Uliassi, Elisa; Korábecný, Jan; PeñaAltamira, Luis Emiliano; Samez, Sarah; Pesaresi, Alessandro; Garcia, Gregory E.; Bartolini, Manuela; Andrisano, Vincenza; Bergamini, Christian; Fato, Romana; Lamba, Doriano; Roberti, Marinella; Kuca, Kamil; Monti, Barbara; Bolognesi, M. L.
X-Ray Diffraction @ Elettra Synchrotron: Atomic Insight Of Your Biomedical Target.
2014 Bais G; Cassetta A; Covaceuszach S; Demitri N; Lamba D; Pesaresi A; Polentarutti M
Evaluation and computational characterization of the facilitated transport of Glc carbon C-1 oxime reactivators across a blood brain barrier model
2013 Bhonsle, ; J, B; Causey, R; Oyler, ; B, L; Bartolucci, C; Lamba, D; Pesaresi, A; Bhamare, ; N, K; Soojhawon, I; Garcia, ; G, E
Enzymatic systems with some potentials in biocatalysis
2012 Lamba D; Pesaresi A; Covaceuszach S; Cassetta; A
Role of metal ions on the activity of Mycobacterium tuberculosis pyrazinamidase
2012 Sheen P; Ferrer P; Gilman; R H; Christiansen G; MorenoRomán P; Gutiérrez; A H; Sotelo J; Evangelista W; Fuentes P; Rueda D; Flores M; Olivera P; Solis J; Pesaresi A; Lamba D; Zimic; M
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Disentangling the formation, mechanism, and evolvement of the covalent methanesulfonyl fluoride acetylcholinesterase adduct: Insights into an aged‐like inactive complex susceptible to reactivation by a combination of nucleophiles | 1-gen-2024 | Stojan, Jure; Pesaresi, Alessandro; Meden, Anže; Lamba, Doriano | |
| Mixed and non-competitive enzyme inhibition: underlying mechanisms andmechanistic irrelevance of the formal two-site model | 1-gen-2023 | Pesaresi, Alessandro | |
| Nonallosteric activation of posttranslational modification enzymes by active site-directed inhibitors | 1-gen-2023 | Pesaresi, Alessandro | |
| Kinetic and structural studies on the inhibition of acetylcholinesterase and butyrylcholinesterase by a series of multitarget-directed galantamine-peptide derivatives | 1-gen-2022 | Pesaresi, A; Lamba, D; Vezenkov, L; Tsekova, D; Lozanov, V | |
| Kinetic Modeling of Time-Dependent Enzyme Inhibition by Pre-Steady-State Analysis of Progress Curves: The Case Study of the Anti-Alzheimer's Drug Galantamine | 1-gen-2022 | Lamba, Doriano; Pesaresi, Alessandro | |
| Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease | 1-gen-2019 | Chalupova K.; Korabecny J.; Bartolini M.; Monti B.; Lamba D.; Caliandro R.; Pesaresi A.; Brazzolotto X.; Gastellier A.J.; Nachon F.; Pejchal J.; Jarosova M.; Hepnarova V.; Jun D.; Hrabinova M.; Dolezal R.; Zdarova Karasova J.; Mzik M.; Kristofikova Z.; Misik J.; Muckova L.; Jost P.; Soukup O.; Benkova M.; Setnicka V.; Habartova L.; Chvojkova M.; Kleteckova L.; Vales K.; Mezeiova E.; Uliassi E.; Valis M.; Nepovimova E.; Bolognesi M.L.; Kuca K. | |
| "Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid Analogues" | 1-gen-2018 | Caliandro R.; Pesaresi A.; Cariati L. Procopio A.; Oliverio M.; Lamba D. | |
| Polypharmacology-based strategies in Alzheimer's disease: the Yin and the Yang of acetylcholinesterase inhibition | 1-gen-2017 | Pesaresi, A; Lamba, D | |
| Polypharmacology-based strategies in Alzheimer's disease: the Yin and the Yang of acetylcholinesterase inhibition | 1-gen-2017 | Pesaresi, A; Lamba, D | |
| Polypharmacology-based strategies in Alzheimer's disease: the Yin and the Yang of acetylcholinesterase inhibition | 1-gen-2017 | Lamba, D; Bartolini, M; Rosini, M; Bolognesi, Ml; Korabecny, J; Zha, X; Pesaresi, A | |
| Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease:Design, Synthesis, Biological Evaluation and X-ray Crystallography | 1-gen-2016 | Zha, Xiaoming; Lamba, Doriano; Zhanga, Lili; A, Yinghan Lou; D, ; Xua, Changxu; Dikanga, ; Chen, Li; Xu, Yungen; Zhang, Luyong; De Simone, Angela; B, Sarah Samez; F, ; Pesaresi, Alessandro; Stojan, Jure; G Lopez, Manuela; Egea, Javier; Vincenzaandrisano, ; Bartolini, Manuela | |
| Polypharmacology-based strategies in Alzheimer's disease: the Yin and the Yan of Acetylcholinesterase inhibition | 1-gen-2016 | Pesaresi A.; Lamba D. | |
| Multi-Target-Directed Ligands in Alzheimer's Disease Treatment | 1-gen-2015 | Pesaresi, A; Samez, S; Bartolini, M; Stojan, J; Garcia, Ge; Zha, X; Bolognesi, Ml; Lamba, D | |
| Multitarget drug design strategy: tacrine-quinone hybrids designed to block amyloid-beta aggregation and to exert anticholinesterase and antioxidant effects | 1-gen-2015 | A. Pesaresi ; S. Samez; E. Nepovimova;; E. Uliassi; J. Korabecny; L.E. PeñaAltamira; G.E. Garcia; M. Bartolini; V. Andrisano; C. Bergamini; R. Fato; M. Roberti; K. Kuca; B. Monti;M.L. Bolognesi;D. Lamba | |
| MULTI-TARGET-DIRECTED LIGANDS IN ALZHEIMER'S DISEASE TREATMENT | 1-gen-2014 | Samez, Sarah; Pesaresi, Alessandro; Bartolini, Manuela; Zha, Xiaoming; Laura Bolognesi, Maria; Lamba, Doriano | |
| Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects | 1-gen-2014 | Nepovímová, Eugenie; Uliassi, Elisa; Korábecný, Jan; PeñaAltamira, Luis Emiliano; Samez, Sarah; Pesaresi, Alessandro; Garcia, Gregory E.; Bartolini, Manuela; Andrisano, Vincenza; Bergamini, Christian; Fato, Romana; Lamba, Doriano; Roberti, Marinella; Kuca, Kamil; Monti, Barbara; Bolognesi, M. L. | |
| X-Ray Diffraction @ Elettra Synchrotron: Atomic Insight Of Your Biomedical Target. | 1-gen-2014 | Bais G; Cassetta A; Covaceuszach S; Demitri N; Lamba D; Pesaresi A; Polentarutti M | |
| Evaluation and computational characterization of the facilitated transport of Glc carbon C-1 oxime reactivators across a blood brain barrier model | 1-gen-2013 | Bhonsle, ; J, B; Causey, R; Oyler, ; B, L; Bartolucci, C; Lamba, D; Pesaresi, A; Bhamare, ; N, K; Soojhawon, I; Garcia, ; G, E | |
| Enzymatic systems with some potentials in biocatalysis | 1-gen-2012 | Lamba D; Pesaresi A; Covaceuszach S; Cassetta; A | |
| Role of metal ions on the activity of Mycobacterium tuberculosis pyrazinamidase | 1-gen-2012 | Sheen P; Ferrer P; Gilman; R H; Christiansen G; MorenoRomán P; Gutiérrez; A H; Sotelo J; Evangelista W; Fuentes P; Rueda D; Flores M; Olivera P; Solis J; Pesaresi A; Lamba D; Zimic; M |