COSSU, FEDERICA
COSSU, FEDERICA
Istituto di Biofisica - IBF - Sede Secondaria Milano
CHCHD4 binding affects the active site of apoptosis inducing factor (AIF): Structural determinants for allosteric regulation
2024 Fagnani, E.; Cocomazzi, P.; Pellegrino, S.; Tedeschi, G.; Scalvini, F. G.; Cossu, F.; Da Vela, S.; Aliverti, A.; Mastrangelo, E.; Milani, M.
Head or tail? A molecular dynamic approach to the complex structure of TNF-associated factor TRAF2
2023 Minicozzi, Velia; Erba, Fulvio; Di Paola, Luisa; Di Venere, Almerinda; Mastrangelo, Eloise; Cossu, Federica; Mei, Giampiero
New Class of Benzodiazepinone Derivatives as Pro-Death Agents Targeting BIR Domains in Cancer Cells
2023 Fiore M.; Mosconi M.; Boni F.; Parodi A.; Salis A.; Tasso B.; Mastrangelo E.; Millo E.; Cossu F.
Ligand Binding in Allosteric Flavoproteins: Part 1. Quantitative Analysis of the Interaction with NAD+ of the Apoptosis Inducing Factor (AIF) Harboring FAD in the Reduced State
2021 Cocomazzi, P; Sorrentino, L; Cossu, F; Aliverti, A
Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-kappa B pathway
2021 Cossu; Federica;Camelliti; Simone;Lecis; Daniele;Sorrentino; Luca;Majorini; Maria Teresa;Milani; Mario;Mastrangelo; Eloise
Computational and experimental characterization of NF023, a candidate anticancer compound inhibiting cIAP2/TRAF2 assembly
2020 Cossu, Federica; Sorrentino, Luca; Fagnani, Elisa; Zaffaroni, Mattia; Milani, Mario; Giorgino, Toni; Mastrangelo, Eloise
Structure-Activity Relationship of NF023 Derivatives Binding to XIAP-BIR1
2019 Sorrentino, L; Cossu, F; Milani, M; Malkoc, B; Huang, Wc; Tsay, Sc; Ru Hwu, J; Mastrangelo, E
Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment
2019 Cossu, F; Milani, M; Mastrangelo, E; Lecis, D
Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs
2018 Corti A; Milani M; Lecis D; Seneci P; de Rosa M; Mastrangelo E; Cossu F
Cellulose production is coupled to sensing of the pyrimidine biosynthetic pathway via c-di-GMP production by the DgcQ protein of Escherichia coli.
2017 Rossi, Elio; Motta, Sara; Aliverti, Alessandro; Cossu, Federica; Gourlay, Louise; Mauri, Pierluigi; Landini, Paolo
Structural bases of the altered catalytic properties of a pathogenic variant of apoptosis inducing factor
2017 Sorrentino, L; Cossu, F; Milani, M; Aliverti, A; Mastrangelo, E
NF023 binding to XIAP-BIR1: Searching drugs for regulation of the NF-kappa B pathway
2015 Cossu, Federica; Milani, Mario; Grassi, Serena; Malvezzi, Francesca; Corti, Alessandro; Bolognesi, Martino; Mastrangelo, Eloise
The activator of apoptosis Smac-DIABLO acts as a tetramer in solution
2015 Mastrangelo, E; Vachette, P; Cossu, F; Malvezzi, F; Bolognesi, M; Milani, M
A NMR and computational study of Smac mimics targeting both the BIR2 and BIR3 domains in XIAP protein
2012 Potenza D.; Belvisi L.; Vasile F.; Moroni E.; Cossu F.; Seneci P.
Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization.
2012 Daniele Lecis; Eloise Mastrangelo; Laura Belvisi; Martino Bolognesi; Monica Civera; Federica Cossu; Michelandrea De Cesare; Domenico Delia; Carmelo Drago; Giacomo Manenti; Leonardo Manzoni; Mario Milani; Elisabetta Moroni; Paola Perego; Donatella Potenza; Vincenzo Rizzo; Cinzia Scavullo; Carlo Scolastico; Federica Servida; Francesca Vasile; Pierfausto Seneci
Structural insights into inhibitor of apoptosis proteins recognition by a potent divalent smac-mimetic.
2012 Cossu, F; Milani, M; Vachette, P; Malvezzi, F; Grassi, S; Lecis, D; Delia, D; Drago, C; Seneci, P; Bolognesi, M; Mastrangelo, E
Recognition of Smac-mimetic compounds by the BIR domain of cIAP1
2010 Cossu, F; Malvezzi, F; Canevari, G; Mastrangelo, E; Lecis, D; Delia, D; Seneci, P; Scolastico, C; Bolognesi, M; Milani, M
Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2
2009 Cossu, Federica; Mastrangelo, Eloise; Milani, Mario; Sorrentino, Graziella; Lecis, Danile; Delia, Domenico; Manzoni, LEONARDO PIERPAOLO; Seneci, Pierfausto; Scolastico, Carlo; Bolognesi, Martino
Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy
2009 Seneci, P.; Bianchi, A.; Battaglia, C.; Belvisi, L.; Bolognesi, M.; Caprini, A.; Cossu, F.; de Franco, E.; de Matteo, M.; Delia, D.; Drago, C.; Khaled, A.; Lecis, D.; Manzoni, L.; Marizzoni, M.; Mastrangelo, E.; Milani, M.; Motto, I.
Targeting the X-Linked Inhibitor of Apoptosis Protein through 4-Substituted Azabicyclo[5.3.0]alkane Smac Mimetics. Structure, Activity, and Recognition Principles
2008 Mastrangelo, E; Cossu, F; Milani, M; Sorrentino, G; Lecis, D; Delia, D; Manzoni, L; Drago, C; Seneci, P; Scolastico, C; Rizzo, V; Bolognesi, M
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| CHCHD4 binding affects the active site of apoptosis inducing factor (AIF): Structural determinants for allosteric regulation | 1-gen-2024 | Fagnani, E.; Cocomazzi, P.; Pellegrino, S.; Tedeschi, G.; Scalvini, F. G.; Cossu, F.; Da Vela, S.; Aliverti, A.; Mastrangelo, E.; Milani, M. | |
| Head or tail? A molecular dynamic approach to the complex structure of TNF-associated factor TRAF2 | 1-gen-2023 | Minicozzi, Velia; Erba, Fulvio; Di Paola, Luisa; Di Venere, Almerinda; Mastrangelo, Eloise; Cossu, Federica; Mei, Giampiero | |
| New Class of Benzodiazepinone Derivatives as Pro-Death Agents Targeting BIR Domains in Cancer Cells | 1-gen-2023 | Fiore M.; Mosconi M.; Boni F.; Parodi A.; Salis A.; Tasso B.; Mastrangelo E.; Millo E.; Cossu F. | |
| Ligand Binding in Allosteric Flavoproteins: Part 1. Quantitative Analysis of the Interaction with NAD+ of the Apoptosis Inducing Factor (AIF) Harboring FAD in the Reduced State | 1-gen-2021 | Cocomazzi, P; Sorrentino, L; Cossu, F; Aliverti, A | |
| Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-kappa B pathway | 1-gen-2021 | Cossu; Federica;Camelliti; Simone;Lecis; Daniele;Sorrentino; Luca;Majorini; Maria Teresa;Milani; Mario;Mastrangelo; Eloise | |
| Computational and experimental characterization of NF023, a candidate anticancer compound inhibiting cIAP2/TRAF2 assembly | 1-gen-2020 | Cossu, Federica; Sorrentino, Luca; Fagnani, Elisa; Zaffaroni, Mattia; Milani, Mario; Giorgino, Toni; Mastrangelo, Eloise | |
| Structure-Activity Relationship of NF023 Derivatives Binding to XIAP-BIR1 | 1-gen-2019 | Sorrentino, L; Cossu, F; Milani, M; Malkoc, B; Huang, Wc; Tsay, Sc; Ru Hwu, J; Mastrangelo, E | |
| Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment | 1-gen-2019 | Cossu, F; Milani, M; Mastrangelo, E; Lecis, D | |
| Structure-based design and molecular profiling of Smac-mimetics selective for cellular IAPs | 1-gen-2018 | Corti A; Milani M; Lecis D; Seneci P; de Rosa M; Mastrangelo E; Cossu F | |
| Cellulose production is coupled to sensing of the pyrimidine biosynthetic pathway via c-di-GMP production by the DgcQ protein of Escherichia coli. | 1-gen-2017 | Rossi, Elio; Motta, Sara; Aliverti, Alessandro; Cossu, Federica; Gourlay, Louise; Mauri, Pierluigi; Landini, Paolo | |
| Structural bases of the altered catalytic properties of a pathogenic variant of apoptosis inducing factor | 1-gen-2017 | Sorrentino, L; Cossu, F; Milani, M; Aliverti, A; Mastrangelo, E | |
| NF023 binding to XIAP-BIR1: Searching drugs for regulation of the NF-kappa B pathway | 1-gen-2015 | Cossu, Federica; Milani, Mario; Grassi, Serena; Malvezzi, Francesca; Corti, Alessandro; Bolognesi, Martino; Mastrangelo, Eloise | |
| The activator of apoptosis Smac-DIABLO acts as a tetramer in solution | 1-gen-2015 | Mastrangelo, E; Vachette, P; Cossu, F; Malvezzi, F; Bolognesi, M; Milani, M | |
| A NMR and computational study of Smac mimics targeting both the BIR2 and BIR3 domains in XIAP protein | 1-gen-2012 | Potenza D.; Belvisi L.; Vasile F.; Moroni E.; Cossu F.; Seneci P. | |
| Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization. | 1-gen-2012 | Daniele Lecis; Eloise Mastrangelo; Laura Belvisi; Martino Bolognesi; Monica Civera; Federica Cossu; Michelandrea De Cesare; Domenico Delia; Carmelo Drago; Giacomo Manenti; Leonardo Manzoni; Mario Milani; Elisabetta Moroni; Paola Perego; Donatella Potenza; Vincenzo Rizzo; Cinzia Scavullo; Carlo Scolastico; Federica Servida; Francesca Vasile; Pierfausto Seneci | |
| Structural insights into inhibitor of apoptosis proteins recognition by a potent divalent smac-mimetic. | 1-gen-2012 | Cossu, F; Milani, M; Vachette, P; Malvezzi, F; Grassi, S; Lecis, D; Delia, D; Drago, C; Seneci, P; Bolognesi, M; Mastrangelo, E | |
| Recognition of Smac-mimetic compounds by the BIR domain of cIAP1 | 1-gen-2010 | Cossu, F; Malvezzi, F; Canevari, G; Mastrangelo, E; Lecis, D; Delia, D; Seneci, P; Scolastico, C; Bolognesi, M; Milani, M | |
| Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2 | 1-gen-2009 | Cossu, Federica; Mastrangelo, Eloise; Milani, Mario; Sorrentino, Graziella; Lecis, Danile; Delia, Domenico; Manzoni, LEONARDO PIERPAOLO; Seneci, Pierfausto; Scolastico, Carlo; Bolognesi, Martino | |
| Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy | 1-gen-2009 | Seneci, P.; Bianchi, A.; Battaglia, C.; Belvisi, L.; Bolognesi, M.; Caprini, A.; Cossu, F.; de Franco, E.; de Matteo, M.; Delia, D.; Drago, C.; Khaled, A.; Lecis, D.; Manzoni, L.; Marizzoni, M.; Mastrangelo, E.; Milani, M.; Motto, I. | |
| Targeting the X-Linked Inhibitor of Apoptosis Protein through 4-Substituted Azabicyclo[5.3.0]alkane Smac Mimetics. Structure, Activity, and Recognition Principles | 1-gen-2008 | Mastrangelo, E; Cossu, F; Milani, M; Sorrentino, G; Lecis, D; Delia, D; Manzoni, L; Drago, C; Seneci, P; Scolastico, C; Rizzo, V; Bolognesi, M |