BROCCOLI, VANIA
BROCCOLI, VANIA
Istituto di Neuroscienze - IN -
A Human Stem Cell-Derived Neurosensory-Epithelial Circuitry on a Chip to Model Herpes Simplex Virus Reactivation
2022 Mazzara Pietro, Giuseppe; Criscuolo, Elena; Rasponi, Marco; Massimino, Luca; Muggeo, Sharon; Palma, Cecilia; Castelli, Matteo; Clementi, Massimo; Burioni, Roberto; Mancini, Nicasio; Broccoli, Vania; Clementi, Nicola
A SOX2-engineered epigenetic silencer factor represses the glioblastoma genetic program and restrains tumor development
2022 Benedetti, Valerio; Banfi, Federica; Zaghi, Mattia; Molldiaz, Raquel; Massimino, Luca; Argelich, Laura; Bellini, Edoardo; Bido, Simone; Muggeo, Sharon; Ordazzo, Gabriele; Mastrototaro, Giuseppina; Moneta, Matteo; Sessa, Alessandro; Broccoli, Vania
CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene BrowZine Journal Cover setd5 Leads to Social Impairments in Zebrafish
2022 Gabellini, Chiara; Pucci, Cecilia; De Cesari, Chiara; Martini, Davide; Di Lauro, Caterina; Digregorio, Matteo; Norton, William; Zippo, Alessio; Sessa, Alessandro; Broccoli, Vania; Andreazzoli, Massimiliano
Pathological mitophagy disrupts mitochondrial homeostasis in Leber's hereditary optic neuropathy
2022 Danese, Alberto; Patergnani, Simone; Maresca, Alessandra; Peron, Camille; Raimondi, Andrea; Caporali, Leonardo; Marchi, Saverio; La Morgia, Chiara; Del Dotto, Valentina; Zanna, Claudia; Iannielli, Angelo; Segnali, Alice; Di Meo, Ivano; Cavaliere, Andrea; LebiedzinskaArciszewska, Magdalena; Wieckowski, Mariusz R.; Martinuzzi, Andrea; MoraesFilho, Milton N.; Salomao, Solange R.; Berezovsky, Adriana; Belfort, Rubens; Buser, Christopher; RossCisneros, Fred N.; Sadun, Alfredo A.; Tacchetti, Carlo; Broccoli, Vania; Giorgi, Carlotta; Tiranti, Valeria; Carelli, Valerio; Pinton, Paolo
Scn1a gene reactivation after symptom onset rescues pathological phenotypes in a mouse model of Dravet syndrome
2022 Valassina, N; Brusco, S; Salamone, A; Serra, L; Luoni, M; Giannelli, S; Bido, S; Massimino, L; Ungaro, F; Mazzara, Pg; D'Adamo, P; Lignani, G; Broccoli, V; Colasante, G
Exploiting hiPSCs in Leber's Hereditary Optic Neuropathy (LHON): Present Achievements and Future Perspectives
2021 Peron, C; Maresca, A; Cavaliere, A; Iannielli, A; Broccoli, V; Carelli, V; Di Meo, I; Tiranti, V
Generation of two human iPSC lines, FINCBi002-A and FINCBi003-A, carrying heteroplasmic macrodeletion of mitochondrial DNA causing Pearson's syndrome
2021 Peron C.; Mauceri R.; Iannielli A.; Cavaliere A.; Legati A.; Rizzo A.; Sciacca F.L.; Broccoli V.; Tiranti V.
Genetics and gene therapy in Dravet syndrome
2021 Higurashi, N; Broccoli, V; Hirose, S
Glucocerebrosidase gene therapy induces alpha-synuclein clearance and neuroprotection of midbrain dopaminergic neurons in mice and macaques
2021 Sucunza, D; Rico, Aj; Roda, E; Collantes, M; Gonzalezaseguinolaza, G; Rodriguezperez, Ai; Penuelas, I; Vazquez, A; Labandeiragarcia, Jl; Broccoli, V; Lanciego, J
Microglia-specific overexpression of ?-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity
2021 Bido, S; Muggeo, S; Massimino, L; Marzi, Mj; Giannelli, Sg; Melacini, E; Nannoni, M; Gambare, D; Bellini, E; Ordazzo, G; Rossi, G; Maffezzini, C; Iannelli, A; Luoni, M; Bagicaluppi, M; Gregori, S; Nicassio, F; Broccoli, V
SETBP1 accumulation induces P53 inhibition and genotoxic stress in neural progenitors underlying neurodegeneration in Schinzel-Giedion syndrome
2021 Banfi F.; Rubio A.; Zaghi M.; Massimino L.; Fagnocchi G.; Bellini E.; Luoni M.; Cancellieri C.; Bagliani A.; Di Resta C.; Maffezzini C.; Ianielli A.; Ferrari M.; Piazza R.; Mologni L.; Broccoli V.; Sessa A.
SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System
2021 Neyrinck, K; Van Den Daele, J; Vervliet, T; De Smedt, J; Wierda, K; Nijs, M; Vanbokhoven, T; D'Hondt, A; Planque, M; Fendt, Sm; Shih, Py; Seibt, F; Almenar, Jp; Kreir, M; Kumar, D; Broccoli, V; Bultynck, G; Ebneth, A; Cabrerasocorro, A; Verfaillie, C
The relevance of mitochondrial DNA variants fluctuation during reprogramming and neuronal differentiation of human iPSCs
2021 Palombo, F; Peron, C; Caporali, L; Iannielli, A; Maresca, A; Di Meo, I; Fiorini, C; Segnali, A; Sciacca, Fl; Rizzo, A; Levi, S; Suomalainen, A; Prigione, A; Broccoli, V; Carelli, V; Tiranti, V
A novel POLR3A genotype leads to leukodystrophy type-7 in two siblings with unusually late age of onset
2020 Campopiano, R; Ferese, R; Zampatti, S; Giardina, E; Biagioni, F; Colonnese, C; Centonze, D; Storto, M; Buttari, F; Fraviga, E; Broccoli, V; Fanelli, M; Fornai, F; Gambardella, S
Frataxin gene editing rescues Friedreich's ataxia pathology in dorsal root ganglia organoid-derived sensory neurons
2020 Mazzara, Pg; Muggeo, S; Luoni, M; Massimino, L; Zaghi, M; Valverde, Ptt; Brusco, S; Marzi, Mj; Palma, C; Colasante, G; Iannielli, A; Paulis, M; Cordiglieri, C; Giannelli, Sg; Podini, P; Gellera, C; Taroni, F; Nicassio, F; Rasponi, M; Broccoli, V
Generation of a human iPSC line, FINCBi001-A, carrying a homoplasmic m.G3460A mutation in MT-ND1 associated with Leber's Hereditary optic Neuropathy (LHON)
2020 Peron C.; Mauceri R.; Cabassi T.; Segnali A.; Maresca A.; Iannielli A.; Rizzo A.; Sciacca F.L.; Broccoli V.; Carelli V.; Tiranti V.
H3K36 Methylation in Neural Development and Associated Diseases
2020 Zaghi, M; Broccoli, V; Sessa, A
In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy
2020 Colasante G.; Qiu Y.; Massimino L.; Di Berardino C.; Cornford J.H.; Snowball A.; Weston M.; Jones S.P.; Giannelli S.; Lieb A.; Schorge S.; Kullmann D.M.; Broccoli V.; Lignani G.
SULT4A1 modulates synaptic development and function by promoting the formation of PSD-95/NMDAR complex
2020 Culotta L.; Scalmani P.; Vinci E.; Terragni B.; Sessa A.; Broccoli V.; Mantegazza M.; Boeckers T.; Verpelli C.
Transdifferentiation of Mouse Embryonic Fibroblasts into Dopaminergic Neurons Reactivates LINE-1 Repetitive Elements
2020 Della Valle F.; Thimma M.P.; Caiazzo M.; Pulcrano S.; Celii M.; Adroub S.A.; Liu P.; AlanisLobato G.; Broccoli V.; Orlando V.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A Human Stem Cell-Derived Neurosensory-Epithelial Circuitry on a Chip to Model Herpes Simplex Virus Reactivation | 1-gen-2022 | Mazzara Pietro, Giuseppe; Criscuolo, Elena; Rasponi, Marco; Massimino, Luca; Muggeo, Sharon; Palma, Cecilia; Castelli, Matteo; Clementi, Massimo; Burioni, Roberto; Mancini, Nicasio; Broccoli, Vania; Clementi, Nicola | |
| A SOX2-engineered epigenetic silencer factor represses the glioblastoma genetic program and restrains tumor development | 1-gen-2022 | Benedetti, Valerio; Banfi, Federica; Zaghi, Mattia; Molldiaz, Raquel; Massimino, Luca; Argelich, Laura; Bellini, Edoardo; Bido, Simone; Muggeo, Sharon; Ordazzo, Gabriele; Mastrototaro, Giuseppina; Moneta, Matteo; Sessa, Alessandro; Broccoli, Vania | |
| CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene BrowZine Journal Cover setd5 Leads to Social Impairments in Zebrafish | 1-gen-2022 | Gabellini, Chiara; Pucci, Cecilia; De Cesari, Chiara; Martini, Davide; Di Lauro, Caterina; Digregorio, Matteo; Norton, William; Zippo, Alessio; Sessa, Alessandro; Broccoli, Vania; Andreazzoli, Massimiliano | |
| Pathological mitophagy disrupts mitochondrial homeostasis in Leber's hereditary optic neuropathy | 1-gen-2022 | Danese, Alberto; Patergnani, Simone; Maresca, Alessandra; Peron, Camille; Raimondi, Andrea; Caporali, Leonardo; Marchi, Saverio; La Morgia, Chiara; Del Dotto, Valentina; Zanna, Claudia; Iannielli, Angelo; Segnali, Alice; Di Meo, Ivano; Cavaliere, Andrea; LebiedzinskaArciszewska, Magdalena; Wieckowski, Mariusz R.; Martinuzzi, Andrea; MoraesFilho, Milton N.; Salomao, Solange R.; Berezovsky, Adriana; Belfort, Rubens; Buser, Christopher; RossCisneros, Fred N.; Sadun, Alfredo A.; Tacchetti, Carlo; Broccoli, Vania; Giorgi, Carlotta; Tiranti, Valeria; Carelli, Valerio; Pinton, Paolo | |
| Scn1a gene reactivation after symptom onset rescues pathological phenotypes in a mouse model of Dravet syndrome | 1-gen-2022 | Valassina, N; Brusco, S; Salamone, A; Serra, L; Luoni, M; Giannelli, S; Bido, S; Massimino, L; Ungaro, F; Mazzara, Pg; D'Adamo, P; Lignani, G; Broccoli, V; Colasante, G | |
| Exploiting hiPSCs in Leber's Hereditary Optic Neuropathy (LHON): Present Achievements and Future Perspectives | 1-gen-2021 | Peron, C; Maresca, A; Cavaliere, A; Iannielli, A; Broccoli, V; Carelli, V; Di Meo, I; Tiranti, V | |
| Generation of two human iPSC lines, FINCBi002-A and FINCBi003-A, carrying heteroplasmic macrodeletion of mitochondrial DNA causing Pearson's syndrome | 1-gen-2021 | Peron C.; Mauceri R.; Iannielli A.; Cavaliere A.; Legati A.; Rizzo A.; Sciacca F.L.; Broccoli V.; Tiranti V. | |
| Genetics and gene therapy in Dravet syndrome | 1-gen-2021 | Higurashi, N; Broccoli, V; Hirose, S | |
| Glucocerebrosidase gene therapy induces alpha-synuclein clearance and neuroprotection of midbrain dopaminergic neurons in mice and macaques | 1-gen-2021 | Sucunza, D; Rico, Aj; Roda, E; Collantes, M; Gonzalezaseguinolaza, G; Rodriguezperez, Ai; Penuelas, I; Vazquez, A; Labandeiragarcia, Jl; Broccoli, V; Lanciego, J | |
| Microglia-specific overexpression of ?-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity | 1-gen-2021 | Bido, S; Muggeo, S; Massimino, L; Marzi, Mj; Giannelli, Sg; Melacini, E; Nannoni, M; Gambare, D; Bellini, E; Ordazzo, G; Rossi, G; Maffezzini, C; Iannelli, A; Luoni, M; Bagicaluppi, M; Gregori, S; Nicassio, F; Broccoli, V | |
| SETBP1 accumulation induces P53 inhibition and genotoxic stress in neural progenitors underlying neurodegeneration in Schinzel-Giedion syndrome | 1-gen-2021 | Banfi F.; Rubio A.; Zaghi M.; Massimino L.; Fagnocchi G.; Bellini E.; Luoni M.; Cancellieri C.; Bagliani A.; Di Resta C.; Maffezzini C.; Ianielli A.; Ferrari M.; Piazza R.; Mologni L.; Broccoli V.; Sessa A. | |
| SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System | 1-gen-2021 | Neyrinck, K; Van Den Daele, J; Vervliet, T; De Smedt, J; Wierda, K; Nijs, M; Vanbokhoven, T; D'Hondt, A; Planque, M; Fendt, Sm; Shih, Py; Seibt, F; Almenar, Jp; Kreir, M; Kumar, D; Broccoli, V; Bultynck, G; Ebneth, A; Cabrerasocorro, A; Verfaillie, C | |
| The relevance of mitochondrial DNA variants fluctuation during reprogramming and neuronal differentiation of human iPSCs | 1-gen-2021 | Palombo, F; Peron, C; Caporali, L; Iannielli, A; Maresca, A; Di Meo, I; Fiorini, C; Segnali, A; Sciacca, Fl; Rizzo, A; Levi, S; Suomalainen, A; Prigione, A; Broccoli, V; Carelli, V; Tiranti, V | |
| A novel POLR3A genotype leads to leukodystrophy type-7 in two siblings with unusually late age of onset | 1-gen-2020 | Campopiano, R; Ferese, R; Zampatti, S; Giardina, E; Biagioni, F; Colonnese, C; Centonze, D; Storto, M; Buttari, F; Fraviga, E; Broccoli, V; Fanelli, M; Fornai, F; Gambardella, S | |
| Frataxin gene editing rescues Friedreich's ataxia pathology in dorsal root ganglia organoid-derived sensory neurons | 1-gen-2020 | Mazzara, Pg; Muggeo, S; Luoni, M; Massimino, L; Zaghi, M; Valverde, Ptt; Brusco, S; Marzi, Mj; Palma, C; Colasante, G; Iannielli, A; Paulis, M; Cordiglieri, C; Giannelli, Sg; Podini, P; Gellera, C; Taroni, F; Nicassio, F; Rasponi, M; Broccoli, V | |
| Generation of a human iPSC line, FINCBi001-A, carrying a homoplasmic m.G3460A mutation in MT-ND1 associated with Leber's Hereditary optic Neuropathy (LHON) | 1-gen-2020 | Peron C.; Mauceri R.; Cabassi T.; Segnali A.; Maresca A.; Iannielli A.; Rizzo A.; Sciacca F.L.; Broccoli V.; Carelli V.; Tiranti V. | |
| H3K36 Methylation in Neural Development and Associated Diseases | 1-gen-2020 | Zaghi, M; Broccoli, V; Sessa, A | |
| In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy | 1-gen-2020 | Colasante G.; Qiu Y.; Massimino L.; Di Berardino C.; Cornford J.H.; Snowball A.; Weston M.; Jones S.P.; Giannelli S.; Lieb A.; Schorge S.; Kullmann D.M.; Broccoli V.; Lignani G. | |
| SULT4A1 modulates synaptic development and function by promoting the formation of PSD-95/NMDAR complex | 1-gen-2020 | Culotta L.; Scalmani P.; Vinci E.; Terragni B.; Sessa A.; Broccoli V.; Mantegazza M.; Boeckers T.; Verpelli C. | |
| Transdifferentiation of Mouse Embryonic Fibroblasts into Dopaminergic Neurons Reactivates LINE-1 Repetitive Elements | 1-gen-2020 | Della Valle F.; Thimma M.P.; Caiazzo M.; Pulcrano S.; Celii M.; Adroub S.A.; Liu P.; AlanisLobato G.; Broccoli V.; Orlando V. |