MASCIA, MARIA PAOLA
MASCIA, MARIA PAOLA
Istituto di Neuroscienze - IN -
GABAA Receptor Modulators with a Pyrazolo[1,5-a]quinazoline Core: Synthesis, Molecular Modelling Studies and Electrophysiological Assays
2022 Letizia Crocetti ; Gabriella Guerrini ; Fabrizio Melani ; Claudia Vergelli ; Maria Paola Mascia ; Maria Paola Giovannoni
'Proximity frequencies' a new parameter to evaluate the profile of GABAA R modulators
2021 Crocetti, Letizia; Guerrini, Gabriella; Cantini, Niccolò; Vergelli, Claudia; Melani, Fabrizio; Mascia, MARIA PAOLA; Giovannoni Maria, Paola
Synthesis of New GABA(A) Receptor Modulator with Pyrazolo[1,5-a]quinazoline (PQ) Scaffold
2019 Guerrini, G.; Vergelli, C.; Cantini, N.; Giovannoni, M. P.; Daniele, S.; Mascia, M. P.; Martini, Cl.; Crocetti, L.
Design, Synthesis, and Biological Evaluation of Imidazo[1,5-a]quinoline as Highly Potent Ligands of Central Benzodiazepine Receptors
2016 Cappelli, A; Anzini, M; Castriconi, F; Grisci, G; Paolino, M; Braile, C; Valenti, S; Giuliani, G; Vomero, S; Di Capua, A; Betti, L; Giannaccini, G; Lucacchini, A; Ghelardini, C; Di Cesare Mannelli, L; Frosini, M; Ricci, L; Giorgi, G; Mascia, Mp; Biggio, G
Differential modulation of GABA(A) receptor function by aryl pyrazoles
2014 Mascia, M.P.; Ledda, G.; Orrù, A.; Marongiu, A.; Loriga, G.; Maciocco, E.; Biggio, G.; Ruiu, S.
Withania somnifera root extract prolongs analgesia and suppresses hyperalgesia in mice treated with morphine.
2014 Orrù, Alessandro; Marchese, Giorgio; Casu, Gianluca; Casu, MARIA ANTONIETTA; Kasture, Sanjay; Cottiglia, Filippo; Acquas, Elio; Mascia, MARIA PAOLA; Anzani, Nicola; Ruiu, Stefania
Hydroxylated biphenyl derivatives are positive modulators of human GABAA receptors
2012 Mascia, MARIA PAOLA; Fabbri, DAVIDE GAETANO; Dettori, MARIA ANTONIETTA; Ledda, Giovanni; Delogu Giovanna, L; Biggio, Giovanni
New Insight into the Central Benzodiazepine Receptor-Ligand Interactions: Design, Synthesis, Biological Evaluation, and Molecular Modeling of 3-Substituted 6-Phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and Related Compounds
2011 Anzini, Maurizio; Valenti, Salvatore; Braile, Carlo; Cappelli, Andrea; Vomero, Salvatore; Acaro, Stefano; Ortuso, Francesco; Marinelli, Luciana; Limongelli, Vittorio; Novellino, Ettore; Betti, Laura; Giannaccini, Gino; Lucacchini, Antonio; Daniele, Simona; Martini, Claudia; Ghelardini, Carla; Mannelli, Lorenzo Di Cesare; Giorgi, Gianluca; Mascia, Maria Paola; Biggio, Giovanni
Thiocolchicoside inhibits the activity of various subtypes of recombinant GABA(A) receptors expressed in Xenopus laevis oocytes
2007 Mascia MP; Bachis E; Obili N; Maciocco E; Cocco GA; Sechi GP; Biggio G.
Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors.
2005 Mascia, Mp; Asproni, B; Busonero, F; Talani, G; Maciocco, E; Pau, A; Cerri, R; Sanna, E; Biggio, G
Novel anellated pyrazoloquinolin-3-ones: synthesis and in vitro BZR activity
2005 Ferlin M.G.; Chiarelotto G.; Dall'Acqua S.; Maciocco E.; Mascia M.P.; Pisu M.G.; Biggio G
Synthesis, structure-activity relationships at the GABA(A) receptor in rat brain, and differential electrophysiological profile at the recombinant human GABA(A) receptor of a series of substituted 1,2-diphenylimidazoles
2005 Asproni, B; Talani, G; Busonero, F; Pau, A; Sanna, S; Cerri, R; Mascia, Mp; Sanna, E; Biggio, G
Channel gating of the glycine receptor changes accessibility to residues implicated in receptor potentiation by alcohols and anesthetics
2004 Lobo I.A. ; Mascia M.P.; Trudell J.R.; Harris R.A.
Inhibition by miltirone of up-regulation of GABAA receptor alfa 4 subunit mRNA by ethanol withdrawal in hippocampal neurons
2004 Mostallino, Mc; Mascia, Mp; Pisu, Mg; Busonero, F; Talani, G; Biggio, G
Gamma-Hydroxybutyric acid and diazepam antagonize a rapid increase in GABA(A) receptors alpha(4) subunit mRNA abundance induced by ethanol withdrawal in cerebellar granule cells.
2003 Follesa, P; Mancuso, L; Biggio, F; Mostallino, Mc; Manca, A; Mascia, Mp; Busonero, F; Talani, G; Sanna, E; Biggio, G
High affinity central benzodiazepine receptor ligands. Part 3: insights into the pharmacophore and pattern recognition study of intrinsic activities of pyrazolo[4,3-c]quinolin-3-ones.
2003 Carotti A; Altomare C; Savini L; Chiasserini L; Pellerano C; Mascia MP; Maciocco E; Busonero F; Mameli M; Biggio G; Sanna E.
Changes in GABA(A) receptor gene expression induced by withdrawal of, but not by long-term exposure to, ganaxolone in cultured rat cerebellar granule cells
2002 Mascia, MP; Biggio, F; Mancuso, L; Cabras, S; Cocco, PL; Gorini, G; Manca, A; Marra, C; Purdy, RH; Follesa, P; Biggio, G
Transgenic expression of a mutant glycine receptor decreases alcohol sensitivity of mice
2002 Findlay, Gs; Wick, Mj; Mascia, Mp; Wallace, D; Miller, Gw; Harris, Ra; Blednov, Ya
Does acetaldehyde mediate ethanol action in the central nervous system?
2001 Mascia, MP; Maiya, R; Borghese, CM; Lobo, IA; Hara, K; Yamakura, T; Gong, DH; Beckstead, MJ
Behavioural changes produced by transgenic overexpression of gamma 2L and gamma 2S subunits of the GABA(A) receptor
2000 Wick, MJ; Radcliffe, RA; Bowers, BJ; Mascia, MP; Luscher, B; Harris, RA; Wehner, JM
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| GABA<sub>A</sub> Receptor Modulators with a Pyrazolo[1,5-a]quinazoline Core: Synthesis, Molecular Modelling Studies and Electrophysiological Assays | 1-gen-2022 | Letizia Crocetti ; Gabriella Guerrini ; Fabrizio Melani ; Claudia Vergelli ; Maria Paola Mascia ; Maria Paola Giovannoni | |
| 'Proximity frequencies' a new parameter to evaluate the profile of GABA<inf>A</inf>R modulators | 1-gen-2021 | Crocetti, Letizia; Guerrini, Gabriella; Cantini, Niccolò; Vergelli, Claudia; Melani, Fabrizio; Mascia, MARIA PAOLA; Giovannoni Maria, Paola | |
| Synthesis of New GABA(A) Receptor Modulator with Pyrazolo[1,5-a]quinazoline (PQ) Scaffold | 1-gen-2019 | Guerrini, G.; Vergelli, C.; Cantini, N.; Giovannoni, M. P.; Daniele, S.; Mascia, M. P.; Martini, Cl.; Crocetti, L. | |
| Design, Synthesis, and Biological Evaluation of Imidazo[1,5-a]quinoline as Highly Potent Ligands of Central Benzodiazepine Receptors | 1-gen-2016 | Cappelli, A; Anzini, M; Castriconi, F; Grisci, G; Paolino, M; Braile, C; Valenti, S; Giuliani, G; Vomero, S; Di Capua, A; Betti, L; Giannaccini, G; Lucacchini, A; Ghelardini, C; Di Cesare Mannelli, L; Frosini, M; Ricci, L; Giorgi, G; Mascia, Mp; Biggio, G | |
| Differential modulation of GABA(A) receptor function by aryl pyrazoles | 1-gen-2014 | Mascia, M.P.; Ledda, G.; Orrù, A.; Marongiu, A.; Loriga, G.; Maciocco, E.; Biggio, G.; Ruiu, S. | |
| Withania somnifera root extract prolongs analgesia and suppresses hyperalgesia in mice treated with morphine. | 1-gen-2014 | Orrù, Alessandro; Marchese, Giorgio; Casu, Gianluca; Casu, MARIA ANTONIETTA; Kasture, Sanjay; Cottiglia, Filippo; Acquas, Elio; Mascia, MARIA PAOLA; Anzani, Nicola; Ruiu, Stefania | |
| Hydroxylated biphenyl derivatives are positive modulators of human GABAA receptors | 1-gen-2012 | Mascia, MARIA PAOLA; Fabbri, DAVIDE GAETANO; Dettori, MARIA ANTONIETTA; Ledda, Giovanni; Delogu Giovanna, L; Biggio, Giovanni | |
| New Insight into the Central Benzodiazepine Receptor-Ligand Interactions: Design, Synthesis, Biological Evaluation, and Molecular Modeling of 3-Substituted 6-Phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and Related Compounds | 1-gen-2011 | Anzini, Maurizio; Valenti, Salvatore; Braile, Carlo; Cappelli, Andrea; Vomero, Salvatore; Acaro, Stefano; Ortuso, Francesco; Marinelli, Luciana; Limongelli, Vittorio; Novellino, Ettore; Betti, Laura; Giannaccini, Gino; Lucacchini, Antonio; Daniele, Simona; Martini, Claudia; Ghelardini, Carla; Mannelli, Lorenzo Di Cesare; Giorgi, Gianluca; Mascia, Maria Paola; Biggio, Giovanni | |
| Thiocolchicoside inhibits the activity of various subtypes of recombinant GABA(A) receptors expressed in Xenopus laevis oocytes | 1-gen-2007 | Mascia MP; Bachis E; Obili N; Maciocco E; Cocco GA; Sechi GP; Biggio G. | |
| Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors. | 1-gen-2005 | Mascia, Mp; Asproni, B; Busonero, F; Talani, G; Maciocco, E; Pau, A; Cerri, R; Sanna, E; Biggio, G | |
| Novel anellated pyrazoloquinolin-3-ones: synthesis and in vitro BZR activity | 1-gen-2005 | Ferlin M.G.; Chiarelotto G.; Dall'Acqua S.; Maciocco E.; Mascia M.P.; Pisu M.G.; Biggio G | |
| Synthesis, structure-activity relationships at the GABA(A) receptor in rat brain, and differential electrophysiological profile at the recombinant human GABA(A) receptor of a series of substituted 1,2-diphenylimidazoles | 1-gen-2005 | Asproni, B; Talani, G; Busonero, F; Pau, A; Sanna, S; Cerri, R; Mascia, Mp; Sanna, E; Biggio, G | |
| Channel gating of the glycine receptor changes accessibility to residues implicated in receptor potentiation by alcohols and anesthetics | 1-gen-2004 | Lobo I.A. ; Mascia M.P.; Trudell J.R.; Harris R.A. | |
| Inhibition by miltirone of up-regulation of GABAA receptor alfa 4 subunit mRNA by ethanol withdrawal in hippocampal neurons | 1-gen-2004 | Mostallino, Mc; Mascia, Mp; Pisu, Mg; Busonero, F; Talani, G; Biggio, G | |
| Gamma-Hydroxybutyric acid and diazepam antagonize a rapid increase in GABA(A) receptors alpha(4) subunit mRNA abundance induced by ethanol withdrawal in cerebellar granule cells. | 1-gen-2003 | Follesa, P; Mancuso, L; Biggio, F; Mostallino, Mc; Manca, A; Mascia, Mp; Busonero, F; Talani, G; Sanna, E; Biggio, G | |
| High affinity central benzodiazepine receptor ligands. Part 3: insights into the pharmacophore and pattern recognition study of intrinsic activities of pyrazolo[4,3-c]quinolin-3-ones. | 1-gen-2003 | Carotti A; Altomare C; Savini L; Chiasserini L; Pellerano C; Mascia MP; Maciocco E; Busonero F; Mameli M; Biggio G; Sanna E. | |
| Changes in GABA(A) receptor gene expression induced by withdrawal of, but not by long-term exposure to, ganaxolone in cultured rat cerebellar granule cells | 1-gen-2002 | Mascia, MP; Biggio, F; Mancuso, L; Cabras, S; Cocco, PL; Gorini, G; Manca, A; Marra, C; Purdy, RH; Follesa, P; Biggio, G | |
| Transgenic expression of a mutant glycine receptor decreases alcohol sensitivity of mice | 1-gen-2002 | Findlay, Gs; Wick, Mj; Mascia, Mp; Wallace, D; Miller, Gw; Harris, Ra; Blednov, Ya | |
| Does acetaldehyde mediate ethanol action in the central nervous system? | 1-gen-2001 | Mascia, MP; Maiya, R; Borghese, CM; Lobo, IA; Hara, K; Yamakura, T; Gong, DH; Beckstead, MJ | |
| Behavioural changes produced by transgenic overexpression of gamma 2L and gamma 2S subunits of the GABA(A) receptor | 1-gen-2000 | Wick, MJ; Radcliffe, RA; Bowers, BJ; Mascia, MP; Luscher, B; Harris, RA; Wehner, JM |