LAMBA, DORIANO
LAMBA, DORIANO
Istituto di Cristallografia - IC
Distinct conformational changes occur within the intrinsically unstructured pro-domain of pro-Nerve Growth Factor in the presence of ATP and Mg2+
2023 Paoletti, Francesca; Covaceuszach, Sonia; Cassetta, Alberto; Calabrese Antonio, N N; Novak, Urban; Konarev, Petr; Grdadolnik, Joze; Lamba, Doriano; Grdadolnik Simona, Golic
The NGF R100W Mutation, Associated with Hereditary Sensory Autonomic Neuropathy Type V, Specifically Affects the Binding Energetic Landscapes of NGF and of Its Precursor proNGF and p75NTR
2023 Covaceuszach; Sonia;Lamba; Doriano
Kinetic and structural studies on the inhibition of acetylcholinesterase and butyrylcholinesterase by a series of multitarget-directed galantamine-peptide derivatives
2022 Pesaresi, A; Lamba, D; Vezenkov, L; Tsekova, D; Lozanov, V
Kinetic Modeling of Time-Dependent Enzyme Inhibition by Pre-Steady-State Analysis of Progress Curves: The Case Study of the Anti-Alzheimer's Drug Galantamine
2022 Doriano Lamba ;Alessandro Pesaresi
Untangling the Conformational Plasticity of V66M Human proBDNF Polymorphism as a Modifier of Psychiatric Disorder Susceptibility
2022 Covaceuszach, S; Peche, Ly; Konarev, Pv; Grdadolnik, J; Cattaneo, A; Lamba, D
A combined evolutionary and structural approach to disclose the primary structural determinants essential for proneurotrophins biological functions
2021 Covaceuszach, S; Peche, Ly; Konarev, Pv; Lamba, D
Endogenous modulators of neurotrophin signaling: Landscape of the transient ATP-NGF interactions
2021 Paoletti, F; Merzel, F; Cassetta, A; Ogris, I; Covaceuszach, S; Grdadolnik, J; Lamba, D; Golic Grdadolnik, S
Peptide-Protein Interactions: From Drug Design to Supramolecular Biomaterials
2021 Caporale, Andrea; Adorinni, Simone; Lamba, Doriano; Saviano, Michele
Small endogenous ligands modulation of nerve growth factor bioactivity: A structural biology overview
2021 Paoletti F.; Lamba D.
The Forgotten Famous: A Tribute to Rififi
2020 Lamba, Doriano; Bartolucci, Cecilia
Enantioselective Synthesis and X Ray determination of (+)((4aS,5S,8aS)-5,8a-dimethyl-7-methyleneoctahydro-2H-spiro [naphthalene-1,2'-[1,3]dioxolan]-5-yl)methyl-4-iodobenzoate
2019 Leonelli F.; Trombetta A.; La Bella A.; Lucarelli G.; Demitri N.; Lamba D.; Migneco L.M.; Marini Bettolo R.
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
2019 Chalupova K.; Korabecny J.; Bartolini M.; Monti B.; Lamba D.; Caliandro R.; Pesaresi A.; Brazzolotto X.; Gastellier A.J.; Nachon F.; Pejchal J.; Jarosova M.; Hepnarova V.; Jun D.; Hrabinova M.; Dolezal R.; Zdarova Karasova J.; Mzik M.; Kristofikova Z.; Misik J.; Muckova L.; Jost P.; Soukup O.; Benkova M.; Setnicka V.; Habartova L.; Chvojkova M.; Kleteckova L.; Vales K.; Mezeiova E.; Uliassi E.; Valis M.; Nepovimova E.; Bolognesi M.L.; Kuca K.
The Pseudomonas aeruginosa lectin LecB binds to the exopolysaccharide Psl and stabilizes the biofilm matrix
2019 da Silva, Daniel Passos; Matwichuk, Michael L.; Townsend, Delaney O.; Reichhardt, Courtney; Lamba, Doriano; Wozniak, Daniel J.; Parsek, Matthew R.
"Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid Analogues"
2018 Caliandro R.; Pesaresi A.; Cariati L. Procopio A.; Oliverio M.; Lamba D.
Copper-Catalyzed C-N Bond Formation via C-H Functionalization: Facile Synthesis of Multisubstituted Imidazo[1,2-a]pyridines from N-(2-Pyridinyl)enaminones
2018 Cacchi, Sandro; Ciogli, Alessia; Demitri, Nicola; Fabrizi, Giancarlo; Ghirga, Francesca; Goggiamani, Antonella; Iazzetti, Antonia; Lamba, Doriano
Structural basis for inhibition of 17beta-hydroxysteroid dehydrogenases by phytoestrogens: the case of fungal 17beta-HSDcl
2017 Cassetta, Alberto; Stojan, Jure; Krastanova, Ivet; Kristan, Katja; Brunskole Svegelj, Mojca; Lamba, Doriano; Lanisnik Rizner, Tea
Conformational rigidity within plasticity promotes differential target recognition of Nerve Growth Factor
2016 Paoletti, Francesca; de Chiara, Cesira; Kelly, Geoff; Covaceuszach, Sonia; Malerba, Francesca; Yan, Robert; Lamba, Doriano; Cattaneo, Antonino; Pastore, Annalisa
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease:Design, Synthesis, Biological Evaluation and X-ray Crystallography
2016 Zha, Xiaoming; Lamba, Doriano; Zhanga, Lili; A, Yinghan Lou; D, ; Xua, Changxu; Dikanga, ; Chen, Li; Xu, Yungen; Zhang, Luyong; De Simone, Angela; B, Sarah Samez; F, ; Pesaresi, Alessandro; Stojan, Jure; G Lopez, Manuela; Egea, Javier; Vincenzaandrisano, ; Bartolini, Manuela
Proof of the Structure of the Stemodia chilensis Tetracyclic Diterpenoid (+)-19-Acetoxystemodan-12-ol by Synthesis from (+)-Podocarpic Acid: X-ray Structure Determination of a Key Intermediate
2016 Leonelli F.; Mostarda A.; De Angelis L.; Lamba D.; Demitri N.; La Bella A.; Ceccacci F.; Migneco L.M.; Marini Bettolo R.
A comparative analysis of the structural, functional and biological differences between Mouse and Human Nerve Growth Factor.
2015 Paoletti, Francesca; Malerba, Francesca; Bruni Ercole, Bruno; Lamba, Doriano; Cattaneo, Antonino
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Distinct conformational changes occur within the intrinsically unstructured pro-domain of pro-Nerve Growth Factor in the presence of ATP and Mg2+ | 1-gen-2023 | Paoletti, Francesca; Covaceuszach, Sonia; Cassetta, Alberto; Calabrese Antonio, N N; Novak, Urban; Konarev, Petr; Grdadolnik, Joze; Lamba, Doriano; Grdadolnik Simona, Golic | |
| The NGF R100W Mutation, Associated with Hereditary Sensory Autonomic Neuropathy Type V, Specifically Affects the Binding Energetic Landscapes of NGF and of Its Precursor proNGF and p75NTR | 1-gen-2023 | Covaceuszach; Sonia;Lamba; Doriano | |
| Kinetic and structural studies on the inhibition of acetylcholinesterase and butyrylcholinesterase by a series of multitarget-directed galantamine-peptide derivatives | 1-gen-2022 | Pesaresi, A; Lamba, D; Vezenkov, L; Tsekova, D; Lozanov, V | |
| Kinetic Modeling of Time-Dependent Enzyme Inhibition by Pre-Steady-State Analysis of Progress Curves: The Case Study of the Anti-Alzheimer's Drug Galantamine | 1-gen-2022 | Doriano Lamba ;Alessandro Pesaresi | |
| Untangling the Conformational Plasticity of V66M Human proBDNF Polymorphism as a Modifier of Psychiatric Disorder Susceptibility | 1-gen-2022 | Covaceuszach, S; Peche, Ly; Konarev, Pv; Grdadolnik, J; Cattaneo, A; Lamba, D | |
| A combined evolutionary and structural approach to disclose the primary structural determinants essential for proneurotrophins biological functions | 1-gen-2021 | Covaceuszach, S; Peche, Ly; Konarev, Pv; Lamba, D | |
| Endogenous modulators of neurotrophin signaling: Landscape of the transient ATP-NGF interactions | 1-gen-2021 | Paoletti, F; Merzel, F; Cassetta, A; Ogris, I; Covaceuszach, S; Grdadolnik, J; Lamba, D; Golic Grdadolnik, S | |
| Peptide-Protein Interactions: From Drug Design to Supramolecular Biomaterials | 1-gen-2021 | Caporale, Andrea; Adorinni, Simone; Lamba, Doriano; Saviano, Michele | |
| Small endogenous ligands modulation of nerve growth factor bioactivity: A structural biology overview | 1-gen-2021 | Paoletti F.; Lamba D. | |
| The Forgotten Famous: A Tribute to Rififi | 1-gen-2020 | Lamba, Doriano; Bartolucci, Cecilia | |
| Enantioselective Synthesis and X Ray determination of (+)((4aS,5S,8aS)-5,8a-dimethyl-7-methyleneoctahydro-2H-spiro [naphthalene-1,2'-[1,3]dioxolan]-5-yl)methyl-4-iodobenzoate | 1-gen-2019 | Leonelli F.; Trombetta A.; La Bella A.; Lucarelli G.; Demitri N.; Lamba D.; Migneco L.M.; Marini Bettolo R. | |
| Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease | 1-gen-2019 | Chalupova K.; Korabecny J.; Bartolini M.; Monti B.; Lamba D.; Caliandro R.; Pesaresi A.; Brazzolotto X.; Gastellier A.J.; Nachon F.; Pejchal J.; Jarosova M.; Hepnarova V.; Jun D.; Hrabinova M.; Dolezal R.; Zdarova Karasova J.; Mzik M.; Kristofikova Z.; Misik J.; Muckova L.; Jost P.; Soukup O.; Benkova M.; Setnicka V.; Habartova L.; Chvojkova M.; Kleteckova L.; Vales K.; Mezeiova E.; Uliassi E.; Valis M.; Nepovimova E.; Bolognesi M.L.; Kuca K. | |
| The Pseudomonas aeruginosa lectin LecB binds to the exopolysaccharide Psl and stabilizes the biofilm matrix | 1-gen-2019 | da Silva, Daniel Passos; Matwichuk, Michael L.; Townsend, Delaney O.; Reichhardt, Courtney; Lamba, Doriano; Wozniak, Daniel J.; Parsek, Matthew R. | |
| "Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid Analogues" | 1-gen-2018 | Caliandro R.; Pesaresi A.; Cariati L. Procopio A.; Oliverio M.; Lamba D. | |
| Copper-Catalyzed C-N Bond Formation via C-H Functionalization: Facile Synthesis of Multisubstituted Imidazo[1,2-a]pyridines from N-(2-Pyridinyl)enaminones | 1-gen-2018 | Cacchi, Sandro; Ciogli, Alessia; Demitri, Nicola; Fabrizi, Giancarlo; Ghirga, Francesca; Goggiamani, Antonella; Iazzetti, Antonia; Lamba, Doriano | |
| Structural basis for inhibition of 17beta-hydroxysteroid dehydrogenases by phytoestrogens: the case of fungal 17beta-HSDcl | 1-gen-2017 | Cassetta, Alberto; Stojan, Jure; Krastanova, Ivet; Kristan, Katja; Brunskole Svegelj, Mojca; Lamba, Doriano; Lanisnik Rizner, Tea | |
| Conformational rigidity within plasticity promotes differential target recognition of Nerve Growth Factor | 1-gen-2016 | Paoletti, Francesca; de Chiara, Cesira; Kelly, Geoff; Covaceuszach, Sonia; Malerba, Francesca; Yan, Robert; Lamba, Doriano; Cattaneo, Antonino; Pastore, Annalisa | |
| Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease:Design, Synthesis, Biological Evaluation and X-ray Crystallography | 1-gen-2016 | Zha, Xiaoming; Lamba, Doriano; Zhanga, Lili; A, Yinghan Lou; D, ; Xua, Changxu; Dikanga, ; Chen, Li; Xu, Yungen; Zhang, Luyong; De Simone, Angela; B, Sarah Samez; F, ; Pesaresi, Alessandro; Stojan, Jure; G Lopez, Manuela; Egea, Javier; Vincenzaandrisano, ; Bartolini, Manuela | |
| Proof of the Structure of the Stemodia chilensis Tetracyclic Diterpenoid (+)-19-Acetoxystemodan-12-ol by Synthesis from (+)-Podocarpic Acid: X-ray Structure Determination of a Key Intermediate | 1-gen-2016 | Leonelli F.; Mostarda A.; De Angelis L.; Lamba D.; Demitri N.; La Bella A.; Ceccacci F.; Migneco L.M.; Marini Bettolo R. | |
| A comparative analysis of the structural, functional and biological differences between Mouse and Human Nerve Growth Factor. | 1-gen-2015 | Paoletti, Francesca; Malerba, Francesca; Bruni Ercole, Bruno; Lamba, Doriano; Cattaneo, Antonino |