MitoRes: A bio-sequences resource for mitochondria-related genes, transcripts and proteins

MitoRes is a comprehensive and non-redundant collection of nuclear-encoded genes and products that target mitochondria in Metazoa. The current version is based on the UniProt release 4 (1-February-2005) and contains 64 different species. The database brings together gene, transcript and protein sequences, gene name, functional product, organelle localization, protein tissue specificity, Enzyme Classification (EC), Gene Ontology (GO) classification, links to other related public databases and protein clusters based on "all-versus-all" global pair-wise alignments. Each cluster derives from intra- and inter- species comparison and integrates information on protein similarity with data on gene. The integration of the protein and gene data helps users to easily get information on conservation of protein sequence and gene structure when compared with their counterparts in other organisms, enabling correlations not possible on the basis of the protein similarity alone and facilitating the selection/extraction of the best candidates for further and deeper investigation. The database can be queried using different search criteria, extract sequences (e.g., gene, intron, exon, UTR, CDS, signal peptide and gene flanking regions up to 5000 bp) in different format, compare protein sequences and gene structure amongst different organisms and perform BLAST alignment of any sequence against the MitoRes collections