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Plasma levels of myeloperoxidase and resistin independently predict mortality in dialysis patients

Background: In patients with kidney failure (KF) undergoing dialysis, neutrophils are dysfunctionally activated. Such chronic activation does not correspond to increased protection against infections and is thought to cause direct vascular damage accounting for the higher incidence of cardiovascular (CV) events. We hypothesized that circulating levels of neutrophil degranulation products (i.e. myeloperoxidase (MPO) and resistin) can predict overall and CV-specific mortality in dialysis patien...

Biocontrol of fungal disease affecting hops: green and sustainable alternatives for the Italian cultivation.

The Italian craft beer market is supporting the demand for local hops. However, hop cultivation and pest management are still challenging. Verticillium spp. (VW), Podosphaera macularis (PM), and Botrytis cinerea (BC) are the main fungi affecting hops, whose current management relies on resistant cultivars and extensive use of fungicides. In 2023, hop roots and rhizomes were sampled and analysed to isolate root-associated bacteria (from the rhi-zosphere and the endosphere) and bacteria harbour...

Dual-regulated lentiviral vector for gene therapy of X-linked chronic granulomatosis

Regulated transgene expression may improve the safety and efficacy of hematopoietic stem cell (HSC) gene therapy. Clinical trials for X-linked chronic granulomatous disease (X-CGD) employing gammaretroviral vectors were limited by insertional oncogenesis or lack of persistent engraftment. Our novel strategy, based on regulated lentiviral vectors (LV), targets gp91 phox expression to the differentiated myeloid compartment while sparing HSC, to reduce the risk of genotoxicity and potential pert...

A New Intronic Variant in ECEL1 in Two Patients with Distal Arthrogryposis Type 5D

: Distal Arthrogryposis type 5D (DA5D) is characterized by congenital contractures involving the distal joints, short stature, scoliosis, ptosis, astigmatism, and dysmorphic features. It is inherited in an autosomal recessive manner, and it is a result of homozygous or compound heterozygous variants in the ECEL1 gene. Here, we report two patients of Sardinian origin harboring a new intronic homozygous variant in ECEL1 (c.1507-9G>A), which was predicted to affect mRNA splicing by activating...

Impact of Surface Finishing on Ti6Al4V Voronoi Additively Manufactured Structures: Morphology, Dimensional Deviation, and Mechanical Behavior

Additively manufactured medical devices require proper surface finishing before their use to remove partially adhered particles and provide adequate surface roughness. The literature widely investigates regular lattice structures—mainly scaffolds with small pores to enhance osseointegration; however, only a few studies have addressed the impact of surface finishing on the dimensional deviation and the global and local mechanical responses of lattice samples. Therefore, the current research in...

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  • DRIOLI, ENRICO1642
  • PASETTO, GAIA1218
  • PASSER, MAURO1202
  • DI MARZO, VINCENZO998
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