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Report sulla valutazione dei laboratori e mostre CNR al Festival della Scienza 2024

Questo contributo presenta i risultati della seconda campagna di monitoraggio condotta dal CNR durante il Festival della Scienza 2024 (Genova, 24 ottobre - 3 novembre), con l’obiettivo di valutare l’efficacia di due laboratori e due mostre interattive. Il lavoro combina approcci quantitativi e qualitativi tramite questionari al pubblico e al personale di animazione scientifica, oltre a osservazioni etnografiche. I dati raccolti mostrano un’elevata soddisfazione dei visitatori e un forte coinv...

Peripheral T cells from multiple sclerosis patients trigger synaptotoxic alterations in central neurons

Aims: The crucial step in the pathogenic events that lead to the development and the progression of multiple sclerosis (MS) is the infiltration of autoreactive T cells in the brain. Data from experimental autoimmune encephalomyelitis (EAE) mice indicate that, together with microglia, T cells are responsible for the enhancement of the glutamatergic transmission in central neurons, contributing to glutamate-mediated excitotoxicity, a pathological hallmark of both EAE and MS brains. Here, we add...

TDP-43 promotes the formation of neuromuscular synapses through the regulation of Disc-large expression in Drosophila skeletal muscles

Background: The ribonuclear protein TDP-43 has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS), with genetic mutations being linked to the neurological symptoms of the disease. Though alterations in the intracellular distribution of TDP-43 have been observed in skeletal muscles of patients suffering from ALS, it is not clear whether such modifications play an active role in the disease or merely represent an expression of muscle homeostatic mechanisms. Also, the ...

Inflammation-Associated Synaptic Alterations as Shared Threads in Depression and Multiple Sclerosis

In the past years, several theories have been advanced to explain the pathogenesis of Major Depressive Disorder (MDD), a neuropsychiatric disease that causes disability in general population. Several theories have been proposed to define the MDD pathophysiology such as the classic “monoamine-theory” or the “glutamate hypothesis.” All these theories have been recently integrated by evidence highlighting inflammation as a pivotal player in developing depressive symptoms. Proinflammatory cytokin...

G-quadruplex Stabilization Fuels the ALT Pathway in ALT-positive Osteosarcoma Cells

Most human tumors maintain telomere lengths by telomerase, whereas a portion of them (10%–15%) uses a mechanism named alternative lengthening of telomeres (ALT). The telomeric G-quadruplex (G4) ligand RHPS4 is known for its potent antiproliferative effect, as shown in telomerase-positive cancer models. Moreover, RHPS4 is also able to reduce cell proliferation in ALT cells, although the influence of G4 stabilization on the ALT mechanism has so far been poorly investigated. Here we show that se...

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  • 01 Contributo su Rivista257353
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  • 08 Report e Working Paper36458
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  • DRIOLI, ENRICO1668
  • PASETTO, GAIA1218
  • PASSER, MAURO1203
  • DI MARZO, VINCENZO1017
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