Pathway landscape and regulatory networks of epigenetically modified Breast Cancer genes

Epigenetic changes are a key regulator of gene expression in different cancer histotypes. After investigating the differentially expressed genes upon treatment with a demethylating agent, e.g. DAC, we performed pathways enrichment analysis and investigated the map of Transcription Factors and microRNAs regulating the epigenetically modified genes. Our results revealed several oncogenic signalling pathways that are altered upon DAC treatment, thus depicting a breast cancer specific pathway landscape. Also, the regulatory maps that have been reported offer a contribution to the understanding of the potential molecular mechanisms induced by DAC therapy.