The mosub package is designed for the identification of multi-optimal subnetworks. The problem is formulated as the multi-objective optimization of two or more functions that are evaluated on subnetworks. The problem is solved using a graph-based version (Mosca and Milanesi 2013) of the Non-dominated Sorting Genetic Algorithm II (NSGA-II) (Deb et al. 2002). Each solution of the problem is a set of identifiers that form a connected subnetwork and genetic operators are designed to modify subnetworks within the constraints of the network they belong to.

mosub: an R Package for the Identification of Multi-Optimal Subnetworks

Ettore Mosca;Luciano Milanesi
2013

Abstract

The mosub package is designed for the identification of multi-optimal subnetworks. The problem is formulated as the multi-objective optimization of two or more functions that are evaluated on subnetworks. The problem is solved using a graph-based version (Mosca and Milanesi 2013) of the Non-dominated Sorting Genetic Algorithm II (NSGA-II) (Deb et al. 2002). Each solution of the problem is a set of identifiers that form a connected subnetwork and genetic operators are designed to modify subnetworks within the constraints of the network they belong to.
2013
Istituto di Tecnologie Biomediche - ITB
Inglese
E Mosca, L Milanesi (2013) Network-based analysis of omics with multi-objective optimization, Molecular Biosystems, 9(12): 2971-80. doi: 10.1039/c3mb70327d
molecular networks
subnetworks
multi-objective optimization
search heuristic
2
Ettore Mosca; Luciano Milanesi
296
none
05 Altro::05.11 Software
info:eu-repo/semantics/other
   Methods for Integrated analysis of Multiple Omics datasets
   MIMOMICS
   FP7
   305280
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/294109
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