D11.5 Clinical Scenarios

This deliverable describes the clinical scenarios obtained by patient data acquisition in different time and data simulation in order to confirm the importance of monitoring patient/device interactions with the future aims of both a therapeutic improvement and VAD support optimization in a single, specific patient as well as a telemedicine platform for management of the increasing number of VAD implanted patients. It reflects the work done to test SensorART platform overcoming the patient's safety limitations preventing from testing the whole platform in a clinical environment, faced during the life span of the project. Different acquisition of data, by invasive procedures and at the time of pre and post-VAD surgical implantations as well as monitoring of patients at the follow up by non-invasive measurements and by sensorized wearable systems (MagIC t shirt and WINPack device) are described. The data simulation of specific patient in different conditions helped the understanding of the monitoring potentialities and accompanied the complex way for entrance of modelling in clinical arena. In many conditions, the models gave indications for the choice of the assistance strategy that should be different, being patient specific. The acquired awareness of the potential benefit derived by interdisciplinary team research has been an important instrument to open the door of the clinical arena, together with the perseverance and the expertise of SensorART Junior Team. Data obtained in patients at the pre-operative and post-operative time of VAD implant and their interpretations gave decision support and useful confirmation for clinicians. The wearable platform, up today not utilized in VAD patients, demonstrated a clear and important applicability, with no interferences, even if still applied to patients without ICD. The modelling and simulation are also applied and reported for data derived within the wearable platform. In fact, this report, mainly built using clinical data, includes the testing of the single components of SensorART platform and the integration tests performed on ARU and hybrid platform. About ARU, the applications described here integrate and complete the work described in the experimental scenario. The simulation work in the clinical scenarios has followed procedures whose methodologies, concerning modelling algorithms, have been already described in previous documents. In summary, the simulation work was aimed at demonstrating possibilities of SensorART platform components and has been dedicated to: Patients' specific simulations Simulation of patients' data sets acquired from wearable devices Experimental integration of the ARU and the hybrid simulator An extended applicability to paediatric congenital heart diseases, including VAD simulation, has been also reported, by documenting the interest induced by the project in other clinical environment.