In this work, a trans-disciplinary experimental-theoretical approach is proposed in order to identify quantitative mechanistic correlations between tumor stromal/microenvironmental parameters and cell behavior. The results will provide insight on resistance factors that limit drug delivery for cancer therapies, and suggest the design of novel nano-carriers to enhance drug transport and release by integrating in vitro, theoretical, and in vivomodels, superior to any actually existing experimental approach.
A trans-disciplinary approach to cancer research
M Mugnano;V de Franciscis;
2019
Abstract
In this work, a trans-disciplinary experimental-theoretical approach is proposed in order to identify quantitative mechanistic correlations between tumor stromal/microenvironmental parameters and cell behavior. The results will provide insight on resistance factors that limit drug delivery for cancer therapies, and suggest the design of novel nano-carriers to enhance drug transport and release by integrating in vitro, theoretical, and in vivomodels, superior to any actually existing experimental approach.File in questo prodotto:
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