The dramatic rise in metabolic disorders associated with obesity in the world population calls for novel therapeutic strategies. The beneficial effects of consuming omega-3 rich marine products as well as fruit and vegetables rich in polyphenols on cardio-metabolic health are well documented. This project aims to develop new anti-diabetic extracts rich in omega-3 and polyphenols from marine and plant biomasses available in large quantities in northern Quebec to meet the demands of the fast-growing sector of nutraceuticals and natural health products. The objectives of this project are: 1. Characterize (physicochemically and microbiologically) biomasses and extracts of marine and plant origin, 2. Develop and optimize the manufacturing processes of ingredients (preparation, extraction, filtration, evaporation drying and packaging) and purification/enrichment of extracts and oils. 3. Identify the most bioactive ingredients and their modes of action by in vitro bioassays 4. Validate the best combinations of ingredients in animal models and the physiological and molecular mechanisms involved. This project involves industrial partners and aimed at developing new products while optimizing extraction and purification processes from nordic marine biomasses containing omega-3 oils rich in DPA as well as different classes of polyphenols from cranberries but also from bark forest residues that are largely unused, all in search of new markets. This project will generate novel omega-3- and polyphenols-rich ingredient combinations from nordic marine and plant biomasses that will have a high potential impact for human health, together with a sustained commercial potential for all the the partners involved.
Targeting the gut microbiota with new extracts enriched with omega-3 PUFAs and polyphenols from nordic biosources to alleviate cardiometabolic diseases
2019
Abstract
The dramatic rise in metabolic disorders associated with obesity in the world population calls for novel therapeutic strategies. The beneficial effects of consuming omega-3 rich marine products as well as fruit and vegetables rich in polyphenols on cardio-metabolic health are well documented. This project aims to develop new anti-diabetic extracts rich in omega-3 and polyphenols from marine and plant biomasses available in large quantities in northern Quebec to meet the demands of the fast-growing sector of nutraceuticals and natural health products. The objectives of this project are: 1. Characterize (physicochemically and microbiologically) biomasses and extracts of marine and plant origin, 2. Develop and optimize the manufacturing processes of ingredients (preparation, extraction, filtration, evaporation drying and packaging) and purification/enrichment of extracts and oils. 3. Identify the most bioactive ingredients and their modes of action by in vitro bioassays 4. Validate the best combinations of ingredients in animal models and the physiological and molecular mechanisms involved. This project involves industrial partners and aimed at developing new products while optimizing extraction and purification processes from nordic marine biomasses containing omega-3 oils rich in DPA as well as different classes of polyphenols from cranberries but also from bark forest residues that are largely unused, all in search of new markets. This project will generate novel omega-3- and polyphenols-rich ingredient combinations from nordic marine and plant biomasses that will have a high potential impact for human health, together with a sustained commercial potential for all the the partners involved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
