Stimuli-responsive polymers containing pH- and redox sensitive moieties are synthesized by random and controlled radical polymerization. Redox sensitive acrylic polymer incorporated porphyrin as photosensitizer, able to produce reactive oxygen species (ROS) when irradiated. Moreover, amphiphilic polymers able to produce nanoparticles due to thermal self-assembly were prepared. In particular, copolymers of oligoethyleneglycol methacrylate (OEGMA) and pentafluorostyrene (PFS) at different compositions were synthesized, and fully characterized in terms of chemical composition, thermal behaviour, an self-assembly properties. The influence of copolymer composition on self-assembly temperature and size of the nanoparticles was evaluated, along with the pH responsiveness of ternary copolymers containing a pH sensitive comonomer, dimethylaminoethyl methacrylate (DMAEMA)
A set of pH- and redox-sensitive nanoparticles based on self-assembling copolymers developed and validated in lab
2018
Abstract
Stimuli-responsive polymers containing pH- and redox sensitive moieties are synthesized by random and controlled radical polymerization. Redox sensitive acrylic polymer incorporated porphyrin as photosensitizer, able to produce reactive oxygen species (ROS) when irradiated. Moreover, amphiphilic polymers able to produce nanoparticles due to thermal self-assembly were prepared. In particular, copolymers of oligoethyleneglycol methacrylate (OEGMA) and pentafluorostyrene (PFS) at different compositions were synthesized, and fully characterized in terms of chemical composition, thermal behaviour, an self-assembly properties. The influence of copolymer composition on self-assembly temperature and size of the nanoparticles was evaluated, along with the pH responsiveness of ternary copolymers containing a pH sensitive comonomer, dimethylaminoethyl methacrylate (DMAEMA)I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
