Extracellular vesicles (EVs) have potential applications in precision medicine, and in the development of next generation cosmeceuticals and nutraceuticals. Generally, the production of EVs from mammalian cells (including mesenchymal cells) is low-yield process, which prompted us to develop and apply new plant-based resources to produce nanometer-sized vesicles. Here, we propose to study ginger-derived nanovesicles (NVs) that has promising health promoting effects. We will also develop a microfluidic platform to evaluate the interaction between NVs and single cells at unprecedented sensitivity and speed. This novel assay uses viable cells trapped and confined in micro wells for assessing cytokine release triggered by the NVs.
Bilateral project CNR-CINVESTAV mEVChip: A microfluidic device to assess the anti-inflammatory effects of ginger-derived nanovesicles on mammalian cells
Immacolata Fiume;
2021
Abstract
Extracellular vesicles (EVs) have potential applications in precision medicine, and in the development of next generation cosmeceuticals and nutraceuticals. Generally, the production of EVs from mammalian cells (including mesenchymal cells) is low-yield process, which prompted us to develop and apply new plant-based resources to produce nanometer-sized vesicles. Here, we propose to study ginger-derived nanovesicles (NVs) that has promising health promoting effects. We will also develop a microfluidic platform to evaluate the interaction between NVs and single cells at unprecedented sensitivity and speed. This novel assay uses viable cells trapped and confined in micro wells for assessing cytokine release triggered by the NVs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
