The University of Turin (UniTO) released the open-access dataset NSCR_Dataset collected for the NEUROSTEMCELLREPAIR (602278) and NSC-Reconstruct (874758) European stem cell consortia for neural cell replacement, reprogramming and functional brain repair (602278) (https://www.nsc-reconstruct.com/en/index.do). NSCR-Dataset is a dataset of analysis of histological ex-vivo brain samples and behavioral parameters from Huntington's Disease (HD) rat models, after cell replacement approach of striatal progenitor cells at the site of grafting - the striatum, at different time point (see for details at short time-points: https://www.sciencedirect.com/science/article/pii/S2213671120301089?via%3Dihub). The UniTO team released this dataset publicly. The dataset contains images of brain tissue stained for different cellular and molecular markers, acquired with transmission and confocal microscopes, from which analysis were performed, and the behavioral data obtained every month by testing the HD animals in different motor tasks. High-resolution images have been acquired; the images will be made available. Copyright: Creative Commons Attribution 4.0 International Open Access

NSCR_Dataset

Belloli S;Moresco RM;
2021

Abstract

The University of Turin (UniTO) released the open-access dataset NSCR_Dataset collected for the NEUROSTEMCELLREPAIR (602278) and NSC-Reconstruct (874758) European stem cell consortia for neural cell replacement, reprogramming and functional brain repair (602278) (https://www.nsc-reconstruct.com/en/index.do). NSCR-Dataset is a dataset of analysis of histological ex-vivo brain samples and behavioral parameters from Huntington's Disease (HD) rat models, after cell replacement approach of striatal progenitor cells at the site of grafting - the striatum, at different time point (see for details at short time-points: https://www.sciencedirect.com/science/article/pii/S2213671120301089?via%3Dihub). The UniTO team released this dataset publicly. The dataset contains images of brain tissue stained for different cellular and molecular markers, acquired with transmission and confocal microscopes, from which analysis were performed, and the behavioral data obtained every month by testing the HD animals in different motor tasks. High-resolution images have been acquired; the images will be made available. Copyright: Creative Commons Attribution 4.0 International Open Access
2021
Istituto di Bioimmagini e Fisiologia Molecolare - IBFM
open science
open data
Huntington Disease
Reg
striatum
cell replacement therapy
human embryonic stem cells
rabies virus-based synaptic tracing
medium spiny neurons
Cell Transplantation
behavioral assessment
brain graft integration
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/445955
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