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Microenvironment influence on stem cells: Pre-carcinogenesis features in the liver of transgenic MMTV-neu (erbB-2) mice bearing mammary tumor.

2005
2005
Istituto di Genetica Molecolare "Luigi Luca Cavalli Sforza"
Altogether, these alterations might be caused by the sustained stress induced by the tumor on the liver. It is assumed that hemopoietic precursors observed in the liver sinusoids were recruited by the tumor for angiogenesis purposes, but also found in the liver a permissive environment for arrest and differentiation. It is recalled that the fate of stem cells/progenitors depends on the environment reached and that cancer is believed to be a stem cell-derived pathology. It is concluded that the final outcome of the activation of a presumably ancestral and nonspecific repair system can be diversified according to the final destination of the activated precursors.
Regenerative medicine
stem cells
angiogenesis
microenvironment
liver
9
276
Freitas, I; Fracchiolla, S; Bertone, R; Vaccarone, R; Baronzio, Gf; Bertone, V; Sacco, Mg; Barni, S; Gerzeli, G
none
info:eu-repo/semantics/book
03 Libro::03.01 Monografia o trattato scientifico
03.01 Monografia o trattato scientifico
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/455355
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