Deliverable D3.1 of the H2020 ALTERNATIVE project (environmentAL Toxicity chEmical mixtuRes through aN innovative platform based on aged cardiac tissue model, Grant agreement ID: 101037090). Search strategy and Data matrix.

The search strategy and data matrix represent the deliverables of task 3.1. To produce these deliverables, the evaluation of epidemiological evidence was performed through a systematic review of scientific literature publications. The objective of this document is to describe the literature search strategy and show the main results collected in the data matrix. This matrix includes relevant information, e.g. sample size, exposure and outcome assessment, and confounding factors, collected from each selected article and reported in this document in separate tables. An external review process of the research protocol led to the definition of the search strategy, the inclusion and exclusion criteria, the outcome selection, and the choice of the quality assessment tool. The protocol and the data quality analysis were developed using standardized procedures, i.e. the PRISMA reporting guideline and the ROBINS-I tool respectively. The revision process ended with the publication of the complete protocol, which is an integral part of this document. The process of revision is described as well as the peer review before publication. The described procedures were carried out during the first 9 months of the project.