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A nanohybrid assembly composed of silver nanoparticles and porphyrins for antimicrobial photodynamic applications

Multifunctional hybrid nanomaterials composed of organic and inorganic components are extensively studied for the improved performances deriving by the combination of chemically different species, thus providing applications in several fields including biomedical applications [1]. If porphyrins are employed as organic components for the construction of multifunctional nanoscale architectures, their ability to act as photosensitizer able to kill bacteria or virus under light exposure enabl...

A Biodegradable Hydrogel based on Captisol®/Porphyrin Nanoassemblies for Antimicrobial Photodynamic Therapy

Current research focuses on developing advanced strategies for microbial control in wound treatment, aiming to effectively neutralize pathogens and overcome multidrug resistance (MDR). In the context of our investigation on phototherapy and photodiagnostics, we have designed "smart" nanoassemblies that encapsulate photosensitizers[1,2] (PS) for antimicrobial photodynamic therapy (aPDT). Here, we present the development of rapidly resorbable hydrogels based on DAC® (a copolymer of hyaluronic a...

A supramolecular assembly made with sulfobutylether-β-cyclodextrin and magnetic Fe3O4 showing water remediation properties.

In literature many examples of magnetic nanohybrids based on cyclodextrins are reported, but they often require multistep processes and preliminary synthetic efforts that affect the scale-up for the final application. In this work, a magnetic hybrid system was produced by supramolecular self-assembly between low-cost precursors: the sulfobutylether-β-cyclodextrin (Captisol®) and magnetic iron oxide-based nanoparticles (MNPs). The interaction between the two was elucidated by spectroscopic (FT...

Supramolecular hybrid nanomaterials composed of metal nanoparticles and cyclodextrins for health applications

Cyclodextrins (CDs) are widely exploited as components of supramolecular functional hybrid nanomaterials in virtue of their well known ability to complex a variety of chemical species within their cavity through host- guest interactions. In combination with inorganic nanomaterials, CDs provide biocompatibility and stability which are very important for biomedical applications [1, 2]. Hybrid nanoassemblies composed of CDs covering metallic nanoparticles (NPs) are here shown. Gold NPs decorated...

Nanohybrids based on amphiphilic B-cyclodextrin for magnetic delivery of a morphogen in microfluidic environments

In tissue engineering, the spatio-temporal regulation of morphogens release is typically achieved using microfluidic devices [1]. Micro- and nanoparticles have been also experienced to deliver morphogens amounts directly onto stem cell cultures, but despite the efficacy of the method it can not offer precise control in the administration [2]. Here a supramolecular nanocarrier (SPION@SC6OH) composed of amphiphilic -cyclodextrin (SC6OH) assemblies entangling superparamagnetic iron oxide nanopa...

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