The invention relates to engineered transporter pro teins comprising at least one fluorescent reporter covalently bound to the transporter protein. The transporter proteins of the present invention comprise a structural inverted repeat motif, with the motif comprising a first and second Subunit that are structural inverted repeats of one another and that are joined to one another by a polypeptide loop. The fluorescent reporter typically is covalently bound to the polypeptide loop that joins the two subunits of the structural inverted repeat.
Transmembrane protein as biosensors
De Michele, Roberto;
2015
Abstract
The invention relates to engineered transporter pro teins comprising at least one fluorescent reporter covalently bound to the transporter protein. The transporter proteins of the present invention comprise a structural inverted repeat motif, with the motif comprising a first and second Subunit that are structural inverted repeats of one another and that are joined to one another by a polypeptide loop. The fluorescent reporter typically is covalently bound to the polypeptide loop that joins the two subunits of the structural inverted repeat.File in questo prodotto:
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