Combinatorial therapeutic regimens based on iminodiacetic acid-substituted cyclodextrins (IDACYDs) are used to treat infections caused by Gram-negative pathogens.IDACYDsfully restore the activity of β-lactam antibiotics against Gram-negative clinical isolates producing the three main MBL enzymes.IDACYDshave a non-toxic profile bothin-vitroandin-vivoand high bioavailability and a well-tolerated and potent pharmaceutical profile.
IMINODIACETIC ACID SUBSTITUTED CYCLODEXTRINS AS POTENTIATORS OF BETA-LACTAM ANTIBIOTICS
Marco Agnes
2019
Abstract
Combinatorial therapeutic regimens based on iminodiacetic acid-substituted cyclodextrins (IDACYDs) are used to treat infections caused by Gram-negative pathogens.IDACYDsfully restore the activity of β-lactam antibiotics against Gram-negative clinical isolates producing the three main MBL enzymes.IDACYDshave a non-toxic profile bothin-vitroandin-vivoand high bioavailability and a well-tolerated and potent pharmaceutical profile.File in questo prodotto:
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