Organic fluorophores for the study of neurovascular coupling through two-photon microscopy techniques: design and synthesis of a potential dual-mode molecular probe

In the limited time of the CNR-MoES project “Organic Fluorophores for the Study of Neurovascular Coupling through Two-Photon Microscopy Techniques” we have developed a model fluorophore that could allow simultaneous fMRI based on 19F signal and functional 2PM imaging, leading to improved holographic image generation for a comprehensive view of the brain at microscopic and/or mesoscopic scale. Correlation of fMRI signal with microscopic cellular dynamics is also expected to assist a better understanding of brain function and the fine neural circuitry, or connectivity