LIGRESTI, ALESSIA
LIGRESTI, ALESSIA
Istituto di Chimica Biomolecolare - ICB - Sede Pozzuoli
DeLA-DrugSelf: Empowering Multi-Objective De Novo Design through SELFIES Molecular Representation
2024 Alberga, Domenico; Lamanna, Giuseppe; Graziano, Giovanni; Delre, Pietro; Cristina Lomuscio, Maria; Corriero, Nicola; Ligresti, Alessia; Siliqi, Dritan; Saviano, Michele; Contino, Marialessandra; Stefanachi, Angela; Mangiatordi, GIUSEPPE FELICE
Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer
2023 Mahmoud, Am; Kostrzewa, M; Marolda, V; Cerasuolo, M; Maccarinelli, F; Coltrini, D; Rezzola, S; Giacomini, A; Mollica, Mp; Motta, A; Paris, D; Zorzano, A; Marzo, Vd; Ronca, R; Ligresti, A
Dual allosteric and orthosteric pharmacology of synthetic analog cannabidiol-dimethylheptyl, but not cannabidiol, on the cannabinoid CB2 receptor
2023 Bouma, Jara; D Broekhuis, Jeremy; van der Horst, Cas; Kumar, Poulami; Ligresti, Alessia; van der Stelt, Mario; H Heitman, Laura
Iron supplementation enhances RSL3-induced ferroptosis to treat naïve and prevent castration-resistant prostate cancer
2023 Maccarinelli, Federica; Coltrini, Daniela; Mussi, Silvia; Bugatti, Mattia; Turati, Marta; Chiodelli, Paola; Giacomini, Arianna; De Cillis, Floriana; Cattane, Nadia; Cattaneo, Annamaria; Ligresti, Alessia; Asperti, Michela; Poli, Maura; Vermi, William; Presta, Marco; Ronca, Roberto
Motifs in Natural Products as Useful Scaffolds to Obtain Novel Benzo[d]imidazole-Based Cannabinoid Type 2 (CB2) Receptor Agonists
2023 Cho, Analia Young Hwa; Chung, Hery; RomeroParra, Javier; Kumar, Poulami; Allarà, Marco; Ligresti, Alessia; GallardoGarrido, Carlos; PessoaMahana, Hernán; Faúndez, Mario; PessoaMahana, Carlos David
Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs
2023 Graziano, Giovanni; Stefanachi, Angela; Contino, Marialessandra; Prietodíaz, Rubén; Ligresti, Alessia; Kumar, Poulami; Scilimati, Antonio; Sotelo, Eddy; Leonetti, Francesco
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R)
2023 Graziano, G; Delre, P; Carofiglio, F; Brea, J; Ligresti, A; Kostrzewa, M; Riganti, C; Gioegallo, C; Majellaro, M; Nicolotti, O; Colabufo, Na; Abate, C; Loza, Mi; Sotelo, E; Mangiatordi, Gf; Contino, M; Stefanachi, A; Leonetti, F
Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor
2023 Mugnaini, Claudia; Kostrzewa, Magdalena; Casini, Marta; Kumar, Poulami; Catallo, Valeria; Allarà, Marco; Guastaferro, Laura; Brizzi, Antonella; Paolino, Marco; Tafi, Andrea; Kapatais, Christelos; Giorgi, Gianluca; Vacondio, Federica; Mor, Marco; Corelli, Federico; Ligresti, Alessia
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase
2022 Intranuovo, Francesca; Brunetti, Leonardo; DelRe, Pietro; Mangiatordi, Giuseppe Felice; Stefanachi, Angela; Laghezza, Antonio; Niso, Mauro; Leonetti, Francesco; Loiodice, Fulvio; Ligresti, Alessia; Kostrzewa, Magdalena; Brea, Jose; Loza, Maria Isabel; Sotelo, Eddy; Saviano, Michele; Colabufo, Nicola Antonio; Riganti, Chiara; Abate, Carmen; Contino, Marialessandra
FGFR blockade by pemigatinib treats naïve and castration resistant prostate cancer
2022 Chiodelli P.; Coltrini D.; Turati M.; Cerasuolo M.; Maccarinelli F.; Rezzola S.; Grillo E.; Giacomini A.; Taranto S.; Mussi S.; Ligresti A.; Presta M.; Ronca R.
N-[1,3-Dialkyl(aryl)-2-oxoimidazolidin-4-ylidene]-aryl(alkyl)sulphonamides as Novel Selective Human Cannabinoid Type 2 Receptor (hCB2R) Ligands; Insights into the Mechanism of Receptor Activation/Deactivation
2022 Gianquinto, Eleonora; Sodano, Federica; Rolando, Barbara; Kostrzewa, Magdalena; Allara, Marco; Mahmoud Ali, Mokhtar; Kumar, Poulami; Spyrakis, Francesca; Ligresti, Alessia; Chegaev, Konstantin
Biosynthesis of the novel endogenous 15-lipoxygenase metabolites N-13-hydroxy-octodecadienoyl-ethanolamine and 13-hydroxy-octodecadienoyl-glycerol by human neutrophils and Eosinophils
2021 Archambault, As; Tinto, F; Dumais, E; Rakotoarivelo, V; Kostrzewa, M; Plante, Pl; Martin, C; Simard, M; Silvestri, C; Pouliot, R; Laviolette, M; Boulet, Lp; Vitale, Rm; Ligresti, A; Di Marzo, V; Flamand, N
Modulation of endocannabinoid tone in osteoblastic differentiation of mc3t3-e1 cells and in mouse bone tissue over time
2021 Kostrzewa M.; Mahmoud A.M.; Verde R.; Di Carlo F.S.; Gianfrancesco F.; Piscitelli F.; Ligresti A.
New Coumarin derivatives as cholinergic and cannabinoid system modulators
2021 Montanari S.; Allara M.; Scalvini L.; Kostrzewa M.; Belluti F.; Gobbi S.; Naldi M.; Rivara S.; Bartolini M.; Ligresti A.; Bisi A.; Rampa A.
Sesquiterpene lactones with the 12,8-guaianolide skeleton from algerian Centaurea omphalotricha
2021 Kebbi, S.; Ciavatta, M. L.; Mahmoud, A. M.; Carbone, M.; Ligresti, A.; Seghiri, R.; Gavagnin Capoggiani, M.
Synthesis and molecular targets of N-13-hydroxy-octadienoyl-ethanolamine, a novel endogenous bioactive 15-lipoxygenase-derived metabolite of N-linoleoyl-ethanolamine found in the skin and saliva
2021 Tinto F.; Archambault A.S.; Dumais E.; Rakotoarivelo V.; Kostrzewa M.; Martin C.; Plante P.L.; Desjardins Y.; Simard M.; Pouliot R.; De Petrocellis L.; Ligresti A.; Di Marzo V.; Flamand N.
Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity In Vivo (vol 63, pg 7369, 2020)
2020 Mugnaini, Claudia; Kostrzewa, Magdalena; Bryk, Marta; Mahmoud, Ali Mokhtar; Brizzi, Antonella; Lamponi, Stefania; Giorgi, Gianluca; Ferlenghi, Francesca; Vacondio, Federica; Maccioni, Paola; Colombo, Giancarlo; Mor, Marco; Starowicz, Katarzyna; Di Marzo, Vincenzo; Ligresti, Alessia; Corelli, Federico
Modeling Acquired Resistance to the Second-Generation Androgen Receptor Antagonist Enzalutamide in the TRAMP Model of Prostate Cancer
2020 Cerasuolo, Marianna; Maccarinelli, Federica; Coltrini, Daniela; Mahmoud, Ali Mokhtar; Marolda, Viviana; Ghedini, Gaia Cristina; Rezzola, Sara; Giacomini, Arianna; Triggiani, Luca; Kostrzewa, Magdalena; Verde, Roberta; Paris, Debora; Melck, Dominique; Presta, Marco; Ligresti, Alessia; Ronca, Roberto
Synthesis of the Major Mammalian Metabolites of THCV
2020 Tinto, Francesco; Villano, Rosaria; Kostrzewa, Magdalena; Ligresti, Alessia; Straker, Hannah; Manzo, Emiliano
Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity
2020 Brizzi, Antonella; Aiello, Francesca; Boccella, Serena; Cascio, Maria Grazia; De Petrocellis, Luciano; Frosini, Maria; Gado, Francesca; Ligresti, Alessia; Luongo, Livio; Marini, Pietro; Mugnaini, Claudia; Pessina, Federica; Corelli, Federico; Maione, Sabatino; Manera, Clementina; Pertwee, Roger G.; Di Marzo, Vincenzo
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| DeLA-DrugSelf: Empowering Multi-Objective De Novo Design through SELFIES Molecular Representation | 1-gen-2024 | Alberga, Domenico; Lamanna, Giuseppe; Graziano, Giovanni; Delre, Pietro; Cristina Lomuscio, Maria; Corriero, Nicola; Ligresti, Alessia; Siliqi, Dritan; Saviano, Michele; Contino, Marialessandra; Stefanachi, Angela; Mangiatordi, GIUSEPPE FELICE | |
| Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer | 1-gen-2023 | Mahmoud, Am; Kostrzewa, M; Marolda, V; Cerasuolo, M; Maccarinelli, F; Coltrini, D; Rezzola, S; Giacomini, A; Mollica, Mp; Motta, A; Paris, D; Zorzano, A; Marzo, Vd; Ronca, R; Ligresti, A | |
| Dual allosteric and orthosteric pharmacology of synthetic analog cannabidiol-dimethylheptyl, but not cannabidiol, on the cannabinoid CB2 receptor | 1-gen-2023 | Bouma, Jara; D Broekhuis, Jeremy; van der Horst, Cas; Kumar, Poulami; Ligresti, Alessia; van der Stelt, Mario; H Heitman, Laura | |
| Iron supplementation enhances RSL3-induced ferroptosis to treat naïve and prevent castration-resistant prostate cancer | 1-gen-2023 | Maccarinelli, Federica; Coltrini, Daniela; Mussi, Silvia; Bugatti, Mattia; Turati, Marta; Chiodelli, Paola; Giacomini, Arianna; De Cillis, Floriana; Cattane, Nadia; Cattaneo, Annamaria; Ligresti, Alessia; Asperti, Michela; Poli, Maura; Vermi, William; Presta, Marco; Ronca, Roberto | |
| Motifs in Natural Products as Useful Scaffolds to Obtain Novel Benzo[d]imidazole-Based Cannabinoid Type 2 (CB2) Receptor Agonists | 1-gen-2023 | Cho, Analia Young Hwa; Chung, Hery; RomeroParra, Javier; Kumar, Poulami; Allarà, Marco; Ligresti, Alessia; GallardoGarrido, Carlos; PessoaMahana, Hernán; Faúndez, Mario; PessoaMahana, Carlos David | |
| Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs | 1-gen-2023 | Graziano, Giovanni; Stefanachi, Angela; Contino, Marialessandra; Prietodíaz, Rubén; Ligresti, Alessia; Kumar, Poulami; Scilimati, Antonio; Sotelo, Eddy; Leonetti, Francesco | |
| N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) | 1-gen-2023 | Graziano, G; Delre, P; Carofiglio, F; Brea, J; Ligresti, A; Kostrzewa, M; Riganti, C; Gioegallo, C; Majellaro, M; Nicolotti, O; Colabufo, Na; Abate, C; Loza, Mi; Sotelo, E; Mangiatordi, Gf; Contino, M; Stefanachi, A; Leonetti, F | |
| Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor | 1-gen-2023 | Mugnaini, Claudia; Kostrzewa, Magdalena; Casini, Marta; Kumar, Poulami; Catallo, Valeria; Allarà, Marco; Guastaferro, Laura; Brizzi, Antonella; Paolino, Marco; Tafi, Andrea; Kapatais, Christelos; Giorgi, Gianluca; Vacondio, Federica; Mor, Marco; Corelli, Federico; Ligresti, Alessia | |
| Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase | 1-gen-2022 | Intranuovo, Francesca; Brunetti, Leonardo; DelRe, Pietro; Mangiatordi, Giuseppe Felice; Stefanachi, Angela; Laghezza, Antonio; Niso, Mauro; Leonetti, Francesco; Loiodice, Fulvio; Ligresti, Alessia; Kostrzewa, Magdalena; Brea, Jose; Loza, Maria Isabel; Sotelo, Eddy; Saviano, Michele; Colabufo, Nicola Antonio; Riganti, Chiara; Abate, Carmen; Contino, Marialessandra | |
| FGFR blockade by pemigatinib treats naïve and castration resistant prostate cancer | 1-gen-2022 | Chiodelli P.; Coltrini D.; Turati M.; Cerasuolo M.; Maccarinelli F.; Rezzola S.; Grillo E.; Giacomini A.; Taranto S.; Mussi S.; Ligresti A.; Presta M.; Ronca R. | |
| N-[1,3-Dialkyl(aryl)-2-oxoimidazolidin-4-ylidene]-aryl(alkyl)sulphonamides as Novel Selective Human Cannabinoid Type 2 Receptor (hCB2R) Ligands; Insights into the Mechanism of Receptor Activation/Deactivation | 1-gen-2022 | Gianquinto, Eleonora; Sodano, Federica; Rolando, Barbara; Kostrzewa, Magdalena; Allara, Marco; Mahmoud Ali, Mokhtar; Kumar, Poulami; Spyrakis, Francesca; Ligresti, Alessia; Chegaev, Konstantin | |
| Biosynthesis of the novel endogenous 15-lipoxygenase metabolites N-13-hydroxy-octodecadienoyl-ethanolamine and 13-hydroxy-octodecadienoyl-glycerol by human neutrophils and Eosinophils | 1-gen-2021 | Archambault, As; Tinto, F; Dumais, E; Rakotoarivelo, V; Kostrzewa, M; Plante, Pl; Martin, C; Simard, M; Silvestri, C; Pouliot, R; Laviolette, M; Boulet, Lp; Vitale, Rm; Ligresti, A; Di Marzo, V; Flamand, N | |
| Modulation of endocannabinoid tone in osteoblastic differentiation of mc3t3-e1 cells and in mouse bone tissue over time | 1-gen-2021 | Kostrzewa M.; Mahmoud A.M.; Verde R.; Di Carlo F.S.; Gianfrancesco F.; Piscitelli F.; Ligresti A. | |
| New Coumarin derivatives as cholinergic and cannabinoid system modulators | 1-gen-2021 | Montanari S.; Allara M.; Scalvini L.; Kostrzewa M.; Belluti F.; Gobbi S.; Naldi M.; Rivara S.; Bartolini M.; Ligresti A.; Bisi A.; Rampa A. | |
| Sesquiterpene lactones with the 12,8-guaianolide skeleton from algerian Centaurea omphalotricha | 1-gen-2021 | Kebbi, S.; Ciavatta, M. L.; Mahmoud, A. M.; Carbone, M.; Ligresti, A.; Seghiri, R.; Gavagnin Capoggiani, M. | |
| Synthesis and molecular targets of N-13-hydroxy-octadienoyl-ethanolamine, a novel endogenous bioactive 15-lipoxygenase-derived metabolite of N-linoleoyl-ethanolamine found in the skin and saliva | 1-gen-2021 | Tinto F.; Archambault A.S.; Dumais E.; Rakotoarivelo V.; Kostrzewa M.; Martin C.; Plante P.L.; Desjardins Y.; Simard M.; Pouliot R.; De Petrocellis L.; Ligresti A.; Di Marzo V.; Flamand N. | |
| Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity In Vivo (vol 63, pg 7369, 2020) | 1-gen-2020 | Mugnaini, Claudia; Kostrzewa, Magdalena; Bryk, Marta; Mahmoud, Ali Mokhtar; Brizzi, Antonella; Lamponi, Stefania; Giorgi, Gianluca; Ferlenghi, Francesca; Vacondio, Federica; Maccioni, Paola; Colombo, Giancarlo; Mor, Marco; Starowicz, Katarzyna; Di Marzo, Vincenzo; Ligresti, Alessia; Corelli, Federico | |
| Modeling Acquired Resistance to the Second-Generation Androgen Receptor Antagonist Enzalutamide in the TRAMP Model of Prostate Cancer | 1-gen-2020 | Cerasuolo, Marianna; Maccarinelli, Federica; Coltrini, Daniela; Mahmoud, Ali Mokhtar; Marolda, Viviana; Ghedini, Gaia Cristina; Rezzola, Sara; Giacomini, Arianna; Triggiani, Luca; Kostrzewa, Magdalena; Verde, Roberta; Paris, Debora; Melck, Dominique; Presta, Marco; Ligresti, Alessia; Ronca, Roberto | |
| Synthesis of the Major Mammalian Metabolites of THCV | 1-gen-2020 | Tinto, Francesco; Villano, Rosaria; Kostrzewa, Magdalena; Ligresti, Alessia; Straker, Hannah; Manzo, Emiliano | |
| Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity | 1-gen-2020 | Brizzi, Antonella; Aiello, Francesca; Boccella, Serena; Cascio, Maria Grazia; De Petrocellis, Luciano; Frosini, Maria; Gado, Francesca; Ligresti, Alessia; Luongo, Livio; Marini, Pietro; Mugnaini, Claudia; Pessina, Federica; Corelli, Federico; Maione, Sabatino; Manera, Clementina; Pertwee, Roger G.; Di Marzo, Vincenzo |