CRESPAN, EMMANUELE
CRESPAN, EMMANUELE
Istituto di Genetica Molecolare "Luigi Luca Cavalli Sforza"
4-Trifluoromethyl bithiazoles as broad-spectrum antimicrobial agents for virus-related bacterial infections or co-infections
2024 Barbieri, Francesca; Carlen, Vincent; Martina, Maria Grazia; Sannio, Filomena; Cancade, Sacha; Perini, Cecilia; Restori, Margherita; Crespan, Emmanuele; Maga, Giovanni; Docquier, Jean-Denis; Cagno, Valeria; Radi, Marco
A novel G-Quadruplex structure within Apolipoprotein E promoter: a new promising target in cancer and dementia fight?
2024 Pirota, Valentina; DELLO STRITTO, Angela; Rita Magnaghi, Lisa; Biesuz, Raffaela; Doria, Filippo; Mella, Mariella; Freccero, Mauro; Crespan, Emmanuele
Applying molecular hybridization to design a new class of pyrazolo[3,4-d]pyrimidines as Src inhibitors active in hepatocellular carcinoma
2024 Di Maria, Salvatore; Passannanti, Raffaele; Poggialini, Federica; Vagaggini, Chiara; Serafinelli, Alessia; Bianchi, Elena; Governa, Paolo; Botta, Lorenzo; Maga, Giovanni; Crespan, Emmanuele; Manetti, Fabrizio; Dreassi, Elena; Musumeci, Francesca; Carbone, Anna; Schenone, Silvia
Bithiazole inhibitors of PI4KB show broad-spectrum antiviral activity against different viral families
2024 Martina, M. G.; Carlen, V.; Van der Reysen, S.; Bianchi, E.; Cabella, N.; Crespan, E.; Radi, M.; Cagno, V.
Synergistic action of human RNaseH2 and the RNA helicase-nuclease DDX3X in processing R-loops
2024 Secchi, Massimiliano; Garbelli, Anna; Riva, Valentina; Deidda, Graziano; Santonicola, Carolina; Formica, Teresa ; Maria, ; Sabbioneda, Simone; Crespan, Emmanuele; Maga, Giovanni
Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4- d]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme
2023 Poggialini, F; Vagaggini, C; Brai, A; Pasqualini, C; Crespan, E; Maga, G; Perini, C; Cabella, N; Botta, L; Musumeci, F; Frosini, M; Schenone, S; Dreassi, E
Identification and Biological Characterization of the Pyrazolo[3,4-d]pyrimidine Derivative SI388 Active as Src Inhibitor
2023 Contadini, C; Cirotti, C; Carbone, A; Norouzi, M; Cianciusi, A; Crespan, E; Perini, C; Maga, G; Barilà, D; Musumeci, F; Schenone, S
Normal and pathogenic variation of RFC1 repeat expansions: implications for clinical diagnosis
2023 Dominik, N.; Magri, S; Currò, R; Abati, E; Facchini, S; Corbetta, M; Macpherson, H; Di Bella, D; Sarto, E; Stevanovski, I; Chintalaphani, Sr; Akcimen, F; Manini, A; Vegezzi, E; Quartesan, I; Montgomery, Ka; Pirota, V; Crespan, E; Perini, C; Grupelli, Gp; Tomaselli, Pj; Marques, W; Genomics England Research, Consortium; Shaw, J; Polke, J; Salsano, E; Fenu, S; Pareyson, D; Pisciotta, C; Tofaris, Gk; Nemeth, Ah; Ealing, J; Radunovic, A; Kearney, S; Kumar, Kr; Vucic, S; Kennerson, M; Reilly, Mm; Houlden, H; Deveson, I; Tucci, A; Taroni, F; Cortese, A
Truncating Variants in RFC1 in Cerebellar Ataxia, Neuropathy, and Vestibular Areflexia Syndrome
2023 Ronco, R; Perini, C; Curro', R; Dominik, N; Facchini, S; Gennari, A; Simone, R; Stuart, S; Nagy, S; Vegezzi, E; Quartesan, I; Elsaddig, A; Lavin, T; Tucci, A; Szymura, A; Novis De Farias, Le; Gary, A; Delfeld, M; Kandikatla, P; Niu, N; Tawde, S; Shaw, J; Polke, J; Reilly, Mm; Wood, Nw; Crespan, E; Gomez, C; Chen, Jyh; Schmahmann, Jd; Gosal, D; Houlden, H; Das, S; Cortese, A
Novel pyrazolo[3,4-d]pyrimidines as dual Src/Bcr-Abl kinase inhibitors: Synthesis and biological evaluation for chronic myeloid leukemia treatment
2022 Di Maria, S; Picarazzi, F; Mori, M; Cianciusi, A; Carbone, A; Crespan, E; Perini, C; Sabetta, S; Deplano, S; Poggialini, F; Molinari, A; Aronne, R; Maccioni, E; Maga, G; Angelucci, A; Schenone, S; Musumeci, F; Dreassi, E
Synthesis and biological activity evaluation of 3-(hetero) arylideneindolin-2-ones as potential c-Src inhibitors
2022 Princiotto, S; Musso, L; Manetti, F; Marcellini, V; Maga, G; Crespan, E; Perini, C; Zaffaroni, N; Beretta, Gl; Dallavalle, S
Towards Innovative Antibacterial Correctors for Cystic Fibrosis Targeting the Lung Microbiome with a Multifunctional Effect
2022 Martina, Maria Grazia; Sannio, Filomena; Crespan, Emmanuele; Pavone, Marialaura; Simoncini, Alice; Barbieri, Francesca; Perini, Cecilia; Pesce, Emanuela; Maga, Giovanni; Pedemonte, Nicoletta; Docquier, Jean‐denis; Radi, Marco
A role for human dna polymerase λ in alternative lengthening of telomeres
2021 Mentegari, E.; Bertoletti, F.; Kissova, M.; Zucca, E.; Galli, S.; Tagliavini, G.; Garbelli, A.; Maffia, A.; Bione, S.; Ferrari, E.; d'Adda di Fagagna, F.; Francia, S.; Sabbioneda, S.; Chen, L. -Y.; Lingner, J.; Bergoglio, V.; Hoffmann, J. -S.; Hubscher, U.; Crespan, E.; Maga, G.
Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIII beta) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus, and Human Rhinoviruses
2021 Grazia Martina, M; Vicenti, I; Bauer, L; Crespan, E; Rango, E; Boccuto, A; Olivieri, N; Incerti, M; Zwaagstra, M; Allodi, M; Bertoni, S; Dreassi, E; Zazzi, M; van Kuppeveld, Fjm; Maga, G; Radi, M
High flexibility of rnaseh2 catalytic activity with respect to non-canonical dna structures
2021 Dede, M; Napolitano, S; Melati, A; Pirota, V; Maga, G; Crespan, E
Selective binding and redox-activity on parallel g-quadruplexes by pegylated naphthalene diimide-copper complexes
2021 Pirota, V; Lunghi, E; Benassi, A; Crespan, E; Freccero, M; Doria, F
System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2
2021 Vicenti, I; Martina, Mg; Boccuto, A; De Angelis, M; Giavarini, G; Dragoni, F; Marchi, S; Trombetta, Cm; Crespan, E; Maga, G; Eydoux, C; Decroly, E; Montomoli, E; Nencioni, L; Zazzi, M; Radi, M
New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains
2020 Nalli, M; Armijos Rivera, Ji; Masci, D; Coluccia, A; Badia, R; Riveiramuñoz, E; Brambilla, A; Cinquina, E; Turriziani, O; Falasca, F; Catalano, M; Limatola, C; Esté, Ja; Maga, G; Silvestri, R; Crespan, E; La Regina, G
Effect of alpha-Methoxy Substitution on the Anti-HIV Activity of Dihydropyrimidin-4(3H)-ones
2019 Nawrozkij M; Forgione M; Yablokov AS; Lucidi A; Tomaselli D; Patsilinakos A; Panella C; Hailu GS; Kirillov IA; Badia R; Riveira Muñoz E; Crespan E; ArmijosRivera JI; Cirilli R; Ragno R; Este JA; Maga G; Mai A; Rotili D.
Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines
2019 Fallacara AL; Passannanti R; Mori M; Iovenitti G; Musumeci F; Greco C; Crespan E; Kissova M; Maga G; Tarantelli C; Spriano F; Gaudio E; Bertoni F; Botta M; Schenone S.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| 4-Trifluoromethyl bithiazoles as broad-spectrum antimicrobial agents for virus-related bacterial infections or co-infections | 1-gen-2024 | Barbieri, Francesca; Carlen, Vincent; Martina, Maria Grazia; Sannio, Filomena; Cancade, Sacha; Perini, Cecilia; Restori, Margherita; Crespan, Emmanuele; Maga, Giovanni; Docquier, Jean-Denis; Cagno, Valeria; Radi, Marco | |
| A novel G-Quadruplex structure within Apolipoprotein E promoter: a new promising target in cancer and dementia fight? | 1-gen-2024 | Pirota, Valentina; DELLO STRITTO, Angela; Rita Magnaghi, Lisa; Biesuz, Raffaela; Doria, Filippo; Mella, Mariella; Freccero, Mauro; Crespan, Emmanuele | |
| Applying molecular hybridization to design a new class of pyrazolo[3,4-d]pyrimidines as Src inhibitors active in hepatocellular carcinoma | 1-gen-2024 | Di Maria, Salvatore; Passannanti, Raffaele; Poggialini, Federica; Vagaggini, Chiara; Serafinelli, Alessia; Bianchi, Elena; Governa, Paolo; Botta, Lorenzo; Maga, Giovanni; Crespan, Emmanuele; Manetti, Fabrizio; Dreassi, Elena; Musumeci, Francesca; Carbone, Anna; Schenone, Silvia | |
| Bithiazole inhibitors of PI4KB show broad-spectrum antiviral activity against different viral families | 1-gen-2024 | Martina, M. G.; Carlen, V.; Van der Reysen, S.; Bianchi, E.; Cabella, N.; Crespan, E.; Radi, M.; Cagno, V. | |
| Synergistic action of human RNaseH2 and the RNA helicase-nuclease DDX3X in processing R-loops | 1-gen-2024 | Secchi, Massimiliano; Garbelli, Anna; Riva, Valentina; Deidda, Graziano; Santonicola, Carolina; Formica, Teresa ; Maria, ; Sabbioneda, Simone; Crespan, Emmanuele; Maga, Giovanni | |
| Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4- d]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme | 1-gen-2023 | Poggialini, F; Vagaggini, C; Brai, A; Pasqualini, C; Crespan, E; Maga, G; Perini, C; Cabella, N; Botta, L; Musumeci, F; Frosini, M; Schenone, S; Dreassi, E | |
| Identification and Biological Characterization of the Pyrazolo[3,4-d]pyrimidine Derivative SI388 Active as Src Inhibitor | 1-gen-2023 | Contadini, C; Cirotti, C; Carbone, A; Norouzi, M; Cianciusi, A; Crespan, E; Perini, C; Maga, G; Barilà, D; Musumeci, F; Schenone, S | |
| Normal and pathogenic variation of RFC1 repeat expansions: implications for clinical diagnosis | 1-gen-2023 | Dominik, N.; Magri, S; Currò, R; Abati, E; Facchini, S; Corbetta, M; Macpherson, H; Di Bella, D; Sarto, E; Stevanovski, I; Chintalaphani, Sr; Akcimen, F; Manini, A; Vegezzi, E; Quartesan, I; Montgomery, Ka; Pirota, V; Crespan, E; Perini, C; Grupelli, Gp; Tomaselli, Pj; Marques, W; Genomics England Research, Consortium; Shaw, J; Polke, J; Salsano, E; Fenu, S; Pareyson, D; Pisciotta, C; Tofaris, Gk; Nemeth, Ah; Ealing, J; Radunovic, A; Kearney, S; Kumar, Kr; Vucic, S; Kennerson, M; Reilly, Mm; Houlden, H; Deveson, I; Tucci, A; Taroni, F; Cortese, A | |
| Truncating Variants in RFC1 in Cerebellar Ataxia, Neuropathy, and Vestibular Areflexia Syndrome | 1-gen-2023 | Ronco, R; Perini, C; Curro', R; Dominik, N; Facchini, S; Gennari, A; Simone, R; Stuart, S; Nagy, S; Vegezzi, E; Quartesan, I; Elsaddig, A; Lavin, T; Tucci, A; Szymura, A; Novis De Farias, Le; Gary, A; Delfeld, M; Kandikatla, P; Niu, N; Tawde, S; Shaw, J; Polke, J; Reilly, Mm; Wood, Nw; Crespan, E; Gomez, C; Chen, Jyh; Schmahmann, Jd; Gosal, D; Houlden, H; Das, S; Cortese, A | |
| Novel pyrazolo[3,4-d]pyrimidines as dual Src/Bcr-Abl kinase inhibitors: Synthesis and biological evaluation for chronic myeloid leukemia treatment | 1-gen-2022 | Di Maria, S; Picarazzi, F; Mori, M; Cianciusi, A; Carbone, A; Crespan, E; Perini, C; Sabetta, S; Deplano, S; Poggialini, F; Molinari, A; Aronne, R; Maccioni, E; Maga, G; Angelucci, A; Schenone, S; Musumeci, F; Dreassi, E | |
| Synthesis and biological activity evaluation of 3-(hetero) arylideneindolin-2-ones as potential c-Src inhibitors | 1-gen-2022 | Princiotto, S; Musso, L; Manetti, F; Marcellini, V; Maga, G; Crespan, E; Perini, C; Zaffaroni, N; Beretta, Gl; Dallavalle, S | |
| Towards Innovative Antibacterial Correctors for Cystic Fibrosis Targeting the Lung Microbiome with a Multifunctional Effect | 1-gen-2022 | Martina, Maria Grazia; Sannio, Filomena; Crespan, Emmanuele; Pavone, Marialaura; Simoncini, Alice; Barbieri, Francesca; Perini, Cecilia; Pesce, Emanuela; Maga, Giovanni; Pedemonte, Nicoletta; Docquier, Jean‐denis; Radi, Marco | |
| A role for human dna polymerase λ in alternative lengthening of telomeres | 1-gen-2021 | Mentegari, E.; Bertoletti, F.; Kissova, M.; Zucca, E.; Galli, S.; Tagliavini, G.; Garbelli, A.; Maffia, A.; Bione, S.; Ferrari, E.; d'Adda di Fagagna, F.; Francia, S.; Sabbioneda, S.; Chen, L. -Y.; Lingner, J.; Bergoglio, V.; Hoffmann, J. -S.; Hubscher, U.; Crespan, E.; Maga, G. | |
| Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIII beta) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus, and Human Rhinoviruses | 1-gen-2021 | Grazia Martina, M; Vicenti, I; Bauer, L; Crespan, E; Rango, E; Boccuto, A; Olivieri, N; Incerti, M; Zwaagstra, M; Allodi, M; Bertoni, S; Dreassi, E; Zazzi, M; van Kuppeveld, Fjm; Maga, G; Radi, M | |
| High flexibility of rnaseh2 catalytic activity with respect to non-canonical dna structures | 1-gen-2021 | Dede, M; Napolitano, S; Melati, A; Pirota, V; Maga, G; Crespan, E | |
| Selective binding and redox-activity on parallel g-quadruplexes by pegylated naphthalene diimide-copper complexes | 1-gen-2021 | Pirota, V; Lunghi, E; Benassi, A; Crespan, E; Freccero, M; Doria, F | |
| System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2 | 1-gen-2021 | Vicenti, I; Martina, Mg; Boccuto, A; De Angelis, M; Giavarini, G; Dragoni, F; Marchi, S; Trombetta, Cm; Crespan, E; Maga, G; Eydoux, C; Decroly, E; Montomoli, E; Nencioni, L; Zazzi, M; Radi, M | |
| New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains | 1-gen-2020 | Nalli, M; Armijos Rivera, Ji; Masci, D; Coluccia, A; Badia, R; Riveiramuñoz, E; Brambilla, A; Cinquina, E; Turriziani, O; Falasca, F; Catalano, M; Limatola, C; Esté, Ja; Maga, G; Silvestri, R; Crespan, E; La Regina, G | |
| Effect of alpha-Methoxy Substitution on the Anti-HIV Activity of Dihydropyrimidin-4(3H)-ones | 1-gen-2019 | Nawrozkij M; Forgione M; Yablokov AS; Lucidi A; Tomaselli D; Patsilinakos A; Panella C; Hailu GS; Kirillov IA; Badia R; Riveira Muñoz E; Crespan E; ArmijosRivera JI; Cirilli R; Ragno R; Este JA; Maga G; Mai A; Rotili D. | |
| Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines | 1-gen-2019 | Fallacara AL; Passannanti R; Mori M; Iovenitti G; Musumeci F; Greco C; Crespan E; Kissova M; Maga G; Tarantelli C; Spriano F; Gaudio E; Bertoni F; Botta M; Schenone S. |