MILANI DE MAYO DE MARI, MARIO
MILANI DE MAYO DE MARI, MARIO
Istituto di Biofisica - IBF
CHCHD4 binding affects the active site of apoptosis inducing factor (AIF): Structural determinants for allosteric regulation
2024 Fagnani, E.; Cocomazzi, P.; Pellegrino, S.; Tedeschi, G.; Scalvini, F. G.; Cossu, F.; Da Vela, S.; Aliverti, A.; Mastrangelo, E.; Milani, M.
Stabilization of the retromer complex: Analysis of novel binding sites of bis-1,3-phenyl guanylhydrazone 2a to the VPS29/VPS35 interface
2024 Fagnani, E.; Bonì, F.; Seneci, P.; Gornati, D.; Muzio, L.; Mastrangelo, E.; MILANI DE MAYO DE MARI, Mario
Virucidal Activity of the Pyridobenzothiazolone Derivative HeE1-17Y against Enveloped RNA Viruses
2022 Bonotto R.M.; Boni F.; Milani M.; ChavesSanjuan A.; Franze S.; Selmin F.; Felicetti T.; Bolognesi M.; Konstantinidou S.; Poggianella M.; Marquez C.L.; Dattola F.; Zoppe M.; Manfroni G.; Mastrangelo E.; Marcello A.
A novel hotspot of gelsolin instability triggers an alternative mechanism of amyloid aggregation
2021 Bollati, Michela; Diomede, Luisa; Giorgino, Toni; Natale, Carmina; Fagnani, Elisa; Boniardi, Irene; Barbiroli, Alberto; Alemani, Rebecca; Beeg, Marten; Gobbi, Marco; Fakin, Ana; Mastrangelo, Eloise; Milani, Mario; Presciuttini, Gianluca; Gabellieri, Edi; Cioni, Patrizia; de Rosa, Matteo
Combined in silico and in vitro approaches identified the antipsychotic drug lurasidone and the antiviral drug elbasvir as SARS-CoV2 and HCoV-OC43 inhibitors
2021 Milani, Mario.; Donalisio, M.; Bonotto, R. M.; Schneider, E.; Arduino, I.; Boni', Francesco.; Lembo, D.; Marcello, A.; Mastrangelo, E.
Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-kappa B pathway
2021 Cossu; Federica;Camelliti; Simone;Lecis; Daniele;Sorrentino; Luca;Majorini; Maria Teresa;Milani; Mario;Mastrangelo; Eloise
Synthesis and Characterization of Novel Mono- And Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult
2021 Gornati D.; Ciccone R.; Vinciguerra A.; Ippati S.; Pannaccione A.; Petrozziello T.; Pizzi E.; Hassan A.; Colombo E.; Barbini S.; Milani M.; Caccavone C.; Randazzo P.; Muzio L.; Annunziato L.; Menegon A.; Secondo A.; Mastrangelo E.; Pignataro G.; Seneci P.
Missense mutations affecting Ca2+-coordination in GCAP1 lead to cone-rod dystrophies by altering protein structural and functional properties
2020 Dal Cortivo, G; Marino, V; Boni, F; Milani, M; Dell'Orco, D
Modulation of guanylate cyclase activating protein 1 (Gcap1) dimeric assembly by ca2+ or mg2+: Hints to understand protein activity
2020 Bonì, Francesco; Marino, Valerio; Bidoia, Carlo; Mastrangelo, Eloise; Barbiroli, Alberto; Dell'Orco, Daniele; Milani, Mario
Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis
2020 Muzio, L; Sirtori, R; Gornati, D; Eleuteri, S; Fossaghi, A; Brancaccio, D; Manzoni, L; Ottoboni, L; Feo, Ld; Quattrini, A; Mastrangelo, E; Sorrentino, L; Scalone, E; Comi, G; Marinelli, L; Riva, N; Milani, M; Seneci, P; Martino, G
The structure of N184K amyloidogenic variant of gelsolin highlights the role of the H-bond network for protein stability and aggregation properties
2020 De Rosa Matteo; Barbiroli Alberto; Bonì Francesco; Scalone Emanuele; Mattioni Davide; Vanoni Maria A.; Patrone Marco; Bollati Michela; Mastrangelo Eloise; Giorgino Toni; Milani Mario
An alternative non-proteolytic mechanism may underlie AGel amyloidosis
2019 Bonì F; Milani M; Mastrangelo E; Babiroli A; Diomede L; de Rosa M
Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions
2019 Cannalire R; Tarantino D; Piorkowski G; Carletti T; Massari S; Felicetti T; Barreca ML; Sabatini S; Tabarrini O; Marcello A; Milani M; Cecchetti V; Mastrangelo E; Manfroni G; Querat G
High-resolution crystal structure of gelsolin domain 2 in complex with the physiological calcium ion
2019 Bollati, M; Scalone, E; Bonì, F; Mastrangelo, E; Giorgino, T; Milani, M; de Rosa, M
Nanobody interaction unveils structure, dynamics and proteotoxicity of the Finnish-type amyloidogenic gelsolin variant
2019 Giorgino, T; Mattioni, D; Hassan, A; Milani, M; Mastrangelo, E; Barbiroli, A; Verhelle, A; Gettemans, J; Barzago, Mm; Diomede, L; de Rosa, M
Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment
2019 Cossu, F; Milani, M; Mastrangelo, E; Lecis, D
Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase
2018 Cannalire, R; Tarantino, D; Astolfi, A; Barreca, Ml; Sabatini, S; Massari, S; Tabarrini, O; Milani, M; Querat, G; Mastrangelo, E; Manfroni, G; Cecchetti, V
Gelsolin pathogenic Gly167Arg mutation promotes domain-swap dimerization of the protein
2018 Bonì, F; Milani, M; Barbiroli, A; Diomede, L; Mastrangelo, E; de Rosa, M
Glycine Amidinotransferase (GATM), Renal Fanconi Syndrome, and Kidney Failure
2018 Reichold, M; Klootwijk, Ed; Reinders, J; Otto, Ea; Milani, M; Broeker, C; Laing, C; Wiesner, J; Devi, S; Zhou, W; Schmitt, R; Tegtmeier, I; Sterner, C; Doellerer, H; Renner, K; Oefner, Pj; Dettmer, K; Simbuerger, Jm; Witzgall, R; Stanescu, Hc; Dumitriu, S; Iancu, D; Patel, V; Mozere, M; Tekman, M; Jaureguiberry, G; Issler, N; Kesselheim, A; Walsh, Sb; Gale, Dp; Howie, Aj; Martins, Jr; Hall, Am; Kasgharian, M; O'Brien, K; Ferreira, Cr; Atwal, Ps; Jain, M; Hammers, A; Charlesedwards, G; Choe, Cu; Isbrandt, D; Cebrianserrano, A; Davies, B; Sandford, Rn; Pugh, C; Konecki, Ds; Povey, S; Bockenhauer, D; Lichterkonecki, U; Gahl, Wa; Unwin, Rj; Warth, R; Kleta, R
Identification of a small molecule that compromises the structural integrity of viroplasms and rotavirus double-layered particles
2018 Eichwald C; De Lorenzo G; Schraner EM; Papa G; Bollati M; Swuec P; de Rosa M; Milani M; Mastrangelo E; Ackermann M; Burrone OR; Arnoldi F
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| CHCHD4 binding affects the active site of apoptosis inducing factor (AIF): Structural determinants for allosteric regulation | 1-gen-2024 | Fagnani, E.; Cocomazzi, P.; Pellegrino, S.; Tedeschi, G.; Scalvini, F. G.; Cossu, F.; Da Vela, S.; Aliverti, A.; Mastrangelo, E.; Milani, M. | |
| Stabilization of the retromer complex: Analysis of novel binding sites of bis-1,3-phenyl guanylhydrazone 2a to the VPS29/VPS35 interface | 1-gen-2024 | Fagnani, E.; Bonì, F.; Seneci, P.; Gornati, D.; Muzio, L.; Mastrangelo, E.; MILANI DE MAYO DE MARI, Mario | |
| Virucidal Activity of the Pyridobenzothiazolone Derivative HeE1-17Y against Enveloped RNA Viruses | 1-gen-2022 | Bonotto R.M.; Boni F.; Milani M.; ChavesSanjuan A.; Franze S.; Selmin F.; Felicetti T.; Bolognesi M.; Konstantinidou S.; Poggianella M.; Marquez C.L.; Dattola F.; Zoppe M.; Manfroni G.; Mastrangelo E.; Marcello A. | |
| A novel hotspot of gelsolin instability triggers an alternative mechanism of amyloid aggregation | 1-gen-2021 | Bollati, Michela; Diomede, Luisa; Giorgino, Toni; Natale, Carmina; Fagnani, Elisa; Boniardi, Irene; Barbiroli, Alberto; Alemani, Rebecca; Beeg, Marten; Gobbi, Marco; Fakin, Ana; Mastrangelo, Eloise; Milani, Mario; Presciuttini, Gianluca; Gabellieri, Edi; Cioni, Patrizia; de Rosa, Matteo | |
| Combined in silico and in vitro approaches identified the antipsychotic drug lurasidone and the antiviral drug elbasvir as SARS-CoV2 and HCoV-OC43 inhibitors | 1-gen-2021 | Milani, Mario.; Donalisio, M.; Bonotto, R. M.; Schneider, E.; Arduino, I.; Boni', Francesco.; Lembo, D.; Marcello, A.; Mastrangelo, E. | |
| Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-kappa B pathway | 1-gen-2021 | Cossu; Federica;Camelliti; Simone;Lecis; Daniele;Sorrentino; Luca;Majorini; Maria Teresa;Milani; Mario;Mastrangelo; Eloise | |
| Synthesis and Characterization of Novel Mono- And Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult | 1-gen-2021 | Gornati D.; Ciccone R.; Vinciguerra A.; Ippati S.; Pannaccione A.; Petrozziello T.; Pizzi E.; Hassan A.; Colombo E.; Barbini S.; Milani M.; Caccavone C.; Randazzo P.; Muzio L.; Annunziato L.; Menegon A.; Secondo A.; Mastrangelo E.; Pignataro G.; Seneci P. | |
| Missense mutations affecting Ca2+-coordination in GCAP1 lead to cone-rod dystrophies by altering protein structural and functional properties | 1-gen-2020 | Dal Cortivo, G; Marino, V; Boni, F; Milani, M; Dell'Orco, D | |
| Modulation of guanylate cyclase activating protein 1 (Gcap1) dimeric assembly by ca2+ or mg2+: Hints to understand protein activity | 1-gen-2020 | Bonì, Francesco; Marino, Valerio; Bidoia, Carlo; Mastrangelo, Eloise; Barbiroli, Alberto; Dell'Orco, Daniele; Milani, Mario | |
| Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis | 1-gen-2020 | Muzio, L; Sirtori, R; Gornati, D; Eleuteri, S; Fossaghi, A; Brancaccio, D; Manzoni, L; Ottoboni, L; Feo, Ld; Quattrini, A; Mastrangelo, E; Sorrentino, L; Scalone, E; Comi, G; Marinelli, L; Riva, N; Milani, M; Seneci, P; Martino, G | |
| The structure of N184K amyloidogenic variant of gelsolin highlights the role of the H-bond network for protein stability and aggregation properties | 1-gen-2020 | De Rosa Matteo; Barbiroli Alberto; Bonì Francesco; Scalone Emanuele; Mattioni Davide; Vanoni Maria A.; Patrone Marco; Bollati Michela; Mastrangelo Eloise; Giorgino Toni; Milani Mario | |
| An alternative non-proteolytic mechanism may underlie AGel amyloidosis | 1-gen-2019 | Bonì F; Milani M; Mastrangelo E; Babiroli A; Diomede L; de Rosa M | |
| Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions | 1-gen-2019 | Cannalire R; Tarantino D; Piorkowski G; Carletti T; Massari S; Felicetti T; Barreca ML; Sabatini S; Tabarrini O; Marcello A; Milani M; Cecchetti V; Mastrangelo E; Manfroni G; Querat G | |
| High-resolution crystal structure of gelsolin domain 2 in complex with the physiological calcium ion | 1-gen-2019 | Bollati, M; Scalone, E; Bonì, F; Mastrangelo, E; Giorgino, T; Milani, M; de Rosa, M | |
| Nanobody interaction unveils structure, dynamics and proteotoxicity of the Finnish-type amyloidogenic gelsolin variant | 1-gen-2019 | Giorgino, T; Mattioni, D; Hassan, A; Milani, M; Mastrangelo, E; Barbiroli, A; Verhelle, A; Gettemans, J; Barzago, Mm; Diomede, L; de Rosa, M | |
| Targeting the BIR Domains of Inhibitor of Apoptosis (IAP) Proteins in Cancer Treatment | 1-gen-2019 | Cossu, F; Milani, M; Mastrangelo, E; Lecis, D | |
| Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase | 1-gen-2018 | Cannalire, R; Tarantino, D; Astolfi, A; Barreca, Ml; Sabatini, S; Massari, S; Tabarrini, O; Milani, M; Querat, G; Mastrangelo, E; Manfroni, G; Cecchetti, V | |
| Gelsolin pathogenic Gly167Arg mutation promotes domain-swap dimerization of the protein | 1-gen-2018 | Bonì, F; Milani, M; Barbiroli, A; Diomede, L; Mastrangelo, E; de Rosa, M | |
| Glycine Amidinotransferase (GATM), Renal Fanconi Syndrome, and Kidney Failure | 1-gen-2018 | Reichold, M; Klootwijk, Ed; Reinders, J; Otto, Ea; Milani, M; Broeker, C; Laing, C; Wiesner, J; Devi, S; Zhou, W; Schmitt, R; Tegtmeier, I; Sterner, C; Doellerer, H; Renner, K; Oefner, Pj; Dettmer, K; Simbuerger, Jm; Witzgall, R; Stanescu, Hc; Dumitriu, S; Iancu, D; Patel, V; Mozere, M; Tekman, M; Jaureguiberry, G; Issler, N; Kesselheim, A; Walsh, Sb; Gale, Dp; Howie, Aj; Martins, Jr; Hall, Am; Kasgharian, M; O'Brien, K; Ferreira, Cr; Atwal, Ps; Jain, M; Hammers, A; Charlesedwards, G; Choe, Cu; Isbrandt, D; Cebrianserrano, A; Davies, B; Sandford, Rn; Pugh, C; Konecki, Ds; Povey, S; Bockenhauer, D; Lichterkonecki, U; Gahl, Wa; Unwin, Rj; Warth, R; Kleta, R | |
| Identification of a small molecule that compromises the structural integrity of viroplasms and rotavirus double-layered particles | 1-gen-2018 | Eichwald C; De Lorenzo G; Schraner EM; Papa G; Bollati M; Swuec P; de Rosa M; Milani M; Mastrangelo E; Ackermann M; Burrone OR; Arnoldi F |