The palladium catalyzed allylic alkylation of soft nucleophiles represents one of the most useful organic transformations. During our recent studies in palladium-catalyzed intramolecular allylic alkylations of activated carboxamides, we noticed that small amounts of cyclization product could be intriguingly attained even in the absence of the enolizating system BSA/AcOK (cat.). In order to shed light on this intriguing result, we decided to examine simple intermolecular reactions either in the presence of BSA/AcOK cat. (method A) or under base-free conditions (method B).
Palladium Catalyzed Alkylation with Allylic Acetates under Neutral Conditions
Giuliano Giambastiani;
1998
Abstract
The palladium catalyzed allylic alkylation of soft nucleophiles represents one of the most useful organic transformations. During our recent studies in palladium-catalyzed intramolecular allylic alkylations of activated carboxamides, we noticed that small amounts of cyclization product could be intriguingly attained even in the absence of the enolizating system BSA/AcOK (cat.). In order to shed light on this intriguing result, we decided to examine simple intermolecular reactions either in the presence of BSA/AcOK cat. (method A) or under base-free conditions (method B).File in questo prodotto:
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