We carried out a highly stereoselective Michael addition (96% de) of nitromethane to enantiomerically pure tricarbonyl(ethyl-4-chloro-2-trimethylsilylcinnamate)chromium(0). This reaction is the key step in the synthesis of (R)-(^)-baclofen, a potent antispastic drug.
Michael addition of nitromethane to non-racemic chiral Cr(CO)3 complexes of ethyl cinnamate derivatives: stereoselective synthesis of (R)-(-)-baclofen
Baldoli Clara;
2000
Abstract
We carried out a highly stereoselective Michael addition (96% de) of nitromethane to enantiomerically pure tricarbonyl(ethyl-4-chloro-2-trimethylsilylcinnamate)chromium(0). This reaction is the key step in the synthesis of (R)-(^)-baclofen, a potent antispastic drug.File in questo prodotto:
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Descrizione: Michael addition of nitromethane to non-racemic chiral Cr(CO)3 complexes of ethyl cinnamate derivatives:stereoselective synthesis of (R)-baclofen
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