The first phosphorous chelate chiral aminophosphinomethyl carbene complex [cyclic] (OC)4Cr:C(Me)N(Me)CH2CH(Ph)PPh2 5 was synthesized. Its conjugate base represents a new chiral ?-unsubstituted amide enolate equiv. for stereoselective addn. reactions. The structure of the major diastereoisomer of the aldol addn. complex between 5 and p-O2NC6H4CHO, solved by x-ray diffraction, shows that the (S)-enantiomer of the conjugated base of 5 reacts preferentially with the re face of the carbonyl function
Synthesis of the first chiral phosphorous chelate aminophosphino-carbene complex and its applications in stereoselective addition reactions
C Baldoli;
1999
Abstract
The first phosphorous chelate chiral aminophosphinomethyl carbene complex [cyclic] (OC)4Cr:C(Me)N(Me)CH2CH(Ph)PPh2 5 was synthesized. Its conjugate base represents a new chiral ?-unsubstituted amide enolate equiv. for stereoselective addn. reactions. The structure of the major diastereoisomer of the aldol addn. complex between 5 and p-O2NC6H4CHO, solved by x-ray diffraction, shows that the (S)-enantiomer of the conjugated base of 5 reacts preferentially with the re face of the carbonyl functionFile in questo prodotto:
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Descrizione: Synthesis of the first chiral phosphorous chelate aminophosphino-carbene complex and its applications in stereoselective addition reactions
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