The synthesis of a hybrid constituted by distamycin A and cysteine labeled with the ?-emitting radionuclide 99mTc to afford the conjugate complex 5 is reported. This new radiopharmaceutical is of potential interest as tumor imaging agent in diagnostic nuclear medicine. The preparation of the hybrid distamycin A-cysteine 4 has been achieved by coupling deformyldistamycin A and Boc-Dmt-OH. Compound 4 was then successfully labeled with 99mTc by reaction with the novel, high-electrophilic, metal-containing fragment [99mTc(N)(PP)]2+ (PP=diphosphine ligand) yielding the 1:1 complex 5.
Synthesis of hybrid distamycin-cysteine labeled with Tc-99m: a model for a novel class of cancer imaging agents
Bolzati C;
2000
Abstract
The synthesis of a hybrid constituted by distamycin A and cysteine labeled with the ?-emitting radionuclide 99mTc to afford the conjugate complex 5 is reported. This new radiopharmaceutical is of potential interest as tumor imaging agent in diagnostic nuclear medicine. The preparation of the hybrid distamycin A-cysteine 4 has been achieved by coupling deformyldistamycin A and Boc-Dmt-OH. Compound 4 was then successfully labeled with 99mTc by reaction with the novel, high-electrophilic, metal-containing fragment [99mTc(N)(PP)]2+ (PP=diphosphine ligand) yielding the 1:1 complex 5.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
prod_223800-doc_53876.pdf
solo utenti autorizzati
Descrizione: Synthesis of Hybrid Distamycin±Cysteine Labeled with 99mTc
Dimensione
199.66 kB
Formato
Adobe PDF
|
199.66 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
