A practical regioselective sulfenylation reaction of the achiral title compound 1 provides desymmetrization and access to C2-symmetric sulphur derivatives. Resolution of 2,2,6,6-tetramethoxy-3,3-dimercapto-1,1-biphenyl 7 was achieved by conversion to the corresponding dithiocarbonate diastereomers. The absolute configuration of (aR)-(-)-7 and (aS)-(+)-7 was assigned unambiguously.
Desymmetrization of 2,2',6,6'-tetrametoxybiphenyl by regioselective sulfenylation reaction
Davide Fabbri;Maria Antonietta Dettori;
2001
Abstract
A practical regioselective sulfenylation reaction of the achiral title compound 1 provides desymmetrization and access to C2-symmetric sulphur derivatives. Resolution of 2,2,6,6-tetramethoxy-3,3-dimercapto-1,1-biphenyl 7 was achieved by conversion to the corresponding dithiocarbonate diastereomers. The absolute configuration of (aR)-(-)-7 and (aS)-(+)-7 was assigned unambiguously.File in questo prodotto:
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