A new nitrogenous metabolite with a p-terphenyl core, sarcodonin (3), has been isolated from fruiting bodies of the basidiomycete Sarcodon leucopus. The structure of 3 was determined through a careful study of its peracetate 4, by use of an array of spectroscopic techniques (including 15N NMR, gradientenhanced, and reverse-detected 2D NMR experiments) and chemical degradation. ROESY data and molecular mechanics (MM+) calculations led to assignment of the absolute configuration of 4. Compound 3 exhibited moderate cytotoxicity against KB and P-388 tumor cell cultures
An Unusual Nitrogenous Terphenyl Derivative from Fruiting Bodies of the Basidiomycete Sarcodon leucopus
Corrada Geraci;Concetta Rocco;
2000
Abstract
A new nitrogenous metabolite with a p-terphenyl core, sarcodonin (3), has been isolated from fruiting bodies of the basidiomycete Sarcodon leucopus. The structure of 3 was determined through a careful study of its peracetate 4, by use of an array of spectroscopic techniques (including 15N NMR, gradientenhanced, and reverse-detected 2D NMR experiments) and chemical degradation. ROESY data and molecular mechanics (MM+) calculations led to assignment of the absolute configuration of 4. Compound 3 exhibited moderate cytotoxicity against KB and P-388 tumor cell culturesFile in questo prodotto:
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