Adjuvant-induced arthritis has been produced in adult rats in order to study the reorganization of serotonergic innervation in the spinal cord dorsal horn in a model of chronic pain. Immunocytochemical detection of CGRP and substance P was quantified with an image analyzer, and we found a transient increase for both peptides at 1 and 2 months, followed by a decrease to control levels after four months. At variance, quantification of serotonergic immunoreactivity showed a significant increase which persisted throughout the study. The significance of this finding is discussed with comparison of other experimental models involving reorganization of primary afferents to the spinal cord.
Modifications of serotonin-, substance P- and calcitonin gene-related peptide-like immunoreactivities in the dorsal horn of the spinal cord of arthritic rats: a quantitative immunocytochemical study.
Marlier L;
1991
Abstract
Adjuvant-induced arthritis has been produced in adult rats in order to study the reorganization of serotonergic innervation in the spinal cord dorsal horn in a model of chronic pain. Immunocytochemical detection of CGRP and substance P was quantified with an image analyzer, and we found a transient increase for both peptides at 1 and 2 months, followed by a decrease to control levels after four months. At variance, quantification of serotonergic immunoreactivity showed a significant increase which persisted throughout the study. The significance of this finding is discussed with comparison of other experimental models involving reorganization of primary afferents to the spinal cord.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
