The fully C-alpha-methylated homo-peptide Ac-[L-(alpha Me)Val](7)-NHiPr is completely 3(10)-helical when its crystals are grown from a methanol solution, whereas it is alpha-helical when crystallized from HFIP (1,1,1,3,3,3-hexafluoropropan-2-ol), thus providing an example of a solvent-driven alpha/3(10)-helix dimorphism in the crystal state. The interactions of cocrystallized HFIP molecules with the peptide in the alpha-helical structure are reported.
Peptide alpha/3(10)-helix dimorphism in the crystal state
Marco Crisma;Michele Saviano;Alessandro Moretto;Claudio Toniolo
2007
Abstract
The fully C-alpha-methylated homo-peptide Ac-[L-(alpha Me)Val](7)-NHiPr is completely 3(10)-helical when its crystals are grown from a methanol solution, whereas it is alpha-helical when crystallized from HFIP (1,1,1,3,3,3-hexafluoropropan-2-ol), thus providing an example of a solvent-driven alpha/3(10)-helix dimorphism in the crystal state. The interactions of cocrystallized HFIP molecules with the peptide in the alpha-helical structure are reported.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
