Truncateddriven nuclear Overhausereffect difference spectra have been used to ascertain the conformational characteristics of the glycosidiclinkage of Adriamycin in aqueous solution. The "two-spin approximation" has been employed to evaluate the cross-relaxation rates between nearby protons and to obtain the relative internuclear distances. The rotational angles ?1 = C(7)-O(7)-C(1?)-(H1?) and ?2 = H(7)-C(7)-O(7)-C(1?) have also been calculated.
A truncated driven Overhauser effect study of Adriamycin in water: Conformation of the glycosidic linkage
Edoardo Trotta
1991
Abstract
Truncateddriven nuclear Overhausereffect difference spectra have been used to ascertain the conformational characteristics of the glycosidiclinkage of Adriamycin in aqueous solution. The "two-spin approximation" has been employed to evaluate the cross-relaxation rates between nearby protons and to obtain the relative internuclear distances. The rotational angles ?1 = C(7)-O(7)-C(1?)-(H1?) and ?2 = H(7)-C(7)-O(7)-C(1?) have also been calculated.File in questo prodotto:
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