The synthesis of new 4-carboxy oxazoles, thiazoles and thiazolidines by condensation of serine or cysteinewith aldehydes or acids is described. Due to the optimization of a mild and selective procedure,which takes advantage of the positive effect of microwave irradiation on the MnO2 mediated oxidationstep, the 2-substituted-4-carboxy derivatives can be obtained in multi-gram scale. Examples of coordinationchemistry to Ni(II) and Co(II) are described.
Selective Synthesis of 2-Substituted 4-Carboxy Oxazoles, Thiazoles and Thiazolidines from Serine or Cysteine Amino Acids
Reginato Gianna;Gonsalvi Luca;Peruzzini Maurizio;Rossin Andrea
2011
Abstract
The synthesis of new 4-carboxy oxazoles, thiazoles and thiazolidines by condensation of serine or cysteinewith aldehydes or acids is described. Due to the optimization of a mild and selective procedure,which takes advantage of the positive effect of microwave irradiation on the MnO2 mediated oxidationstep, the 2-substituted-4-carboxy derivatives can be obtained in multi-gram scale. Examples of coordinationchemistry to Ni(II) and Co(II) are described.File in questo prodotto:
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Descrizione: Selective Synthesis of 2-Substituted 4-Carboxy Oxazoles, Thiazoles and Thiazolidines
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