A series of chiral 1,4-morpholin-2,5-dione derivatives were synthesized starting from chiral synthons 1 and 2, monolactim ethers derived from L- valine, and the absolute configurations of the new stereocentres were assigned. The substrates investigated behave as noncompetitive inhibitors against alpha-glucosidases and Eire inactive towards beta-glucosidase, alpha-mannosidase and alpha-galactosidase. Three of these substrates show very good and specific inhibition abilities towards alpha-glucosidase.
Synthesis of new chiral 1,4-morpholin-2,5-dione derivatives and evaluation as alpha-glucosidase inhibitors. Part 3
Sandri Monica
2007
Abstract
A series of chiral 1,4-morpholin-2,5-dione derivatives were synthesized starting from chiral synthons 1 and 2, monolactim ethers derived from L- valine, and the absolute configurations of the new stereocentres were assigned. The substrates investigated behave as noncompetitive inhibitors against alpha-glucosidases and Eire inactive towards beta-glucosidase, alpha-mannosidase and alpha-galactosidase. Three of these substrates show very good and specific inhibition abilities towards alpha-glucosidase.File in questo prodotto:
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