The enantiomers of D- and L-tryptophan were separated by capillary electrophore- sis, using a-cyclodextrin as a chiral active component in the background electrolyte. The separation of (-) and (+) epinephrine was achieved by supplementing the background electrolyte with Heptakis (2,6-di-O-methyl-~-cyclodextrin). As a prac- tical application ofthe method, the quantitative analysis of(-)and( +)enantiomenin commercial pharmaceutical solutions of adrenaline is shown.
Enantiomer resolution by using capillary zone electrophoresis: resolution of racemic tryptophan and determination of the enantiomer composition of commercial pharmaceutical epinephrine
Salvatore Fanali;
1990
Abstract
The enantiomers of D- and L-tryptophan were separated by capillary electrophore- sis, using a-cyclodextrin as a chiral active component in the background electrolyte. The separation of (-) and (+) epinephrine was achieved by supplementing the background electrolyte with Heptakis (2,6-di-O-methyl-~-cyclodextrin). As a prac- tical application ofthe method, the quantitative analysis of(-)and( +)enantiomenin commercial pharmaceutical solutions of adrenaline is shown.File in questo prodotto:
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