SUMMARY Objective In type-1 diabetes mellitus (T1DM), the release of many hormones, not only from beta-cells, but also from adipocytes (adipokines) may be altered. After successful pancreas-kidney-transplantation (PKTx), T1DM patients can revert to a non-diabetic metabolism, but it is unclear whether alterations of adipokines are still present after PKTx. Design, patients and measurements Concentrations of adipokines [visfatin, retinol-binding protein-4 (RBP-4), adiponectin, high-molecular-weight (HMW) adiponectin] were measured at fasting in 10 PKTx and in 19 T1DM. Non diabetic healthy controls (CON, n=9) and 6 non-diabetic patients after kidney transplantation (KTx) were examined as control groups. In PKTx, KTx and CON, indices of insulin sensitivity (OGIS) and beta-cell function (Adaptation Index) were calculated from 75g-oral glucose-tolerance-test (OGTT) data. Results Fasting serum visfatin (T1DM: 56+/-4mug/L, PKTx: 42+/-6mug/L, KTx: 39+/-3mug/L, CON: 40+/-3 mug/L) and RBP-4 (T1DM: 490+/-26mug/L, PKTx: 346+/-39mug/L, KTx: 401+/-13mug/L, CON: 359+/-36mug/L) were increased by 40% and 36% respectively (each p<0.03) in T1DM only. Levels were positively correlated with HbA1c in all subjects (visfatin: r=0.43, p<0.004; RBP-4: r=0.46, p<0.03). Fasting plasma adiponectin was 80% higher in T1DM and in PKTx (T1DM: 18+/-2mg/L, PKTx: 18+/-3mg/L, KTx: 12+/-3mg/L, CON: 10+/-1mg/L;p<0.04) and was positively correlated with diabetes duration (r=0.37, p<0.02). HMW/total adiponectin ratio was increased in T1DM (p<0.02). PKTx displayed a normoglycaemic metabolism, were as insulin sensitive as CON, but adaptation index was lower than in CON and KT (p<0.01). Conclusions T1DM after successful PKTx show normal fasting visfatin and RBP-4 levels and HMW-adiponectin/adiponectin-ratio, which are elevated in T1DM, whereas total adiponectin levels are similarly increased in T1DM and PKTx patients.
Adipokines in type-1 diabetes after successful pancreas transplantation: Normal visfatin and retinol-binding-protein-4, but increased total adiponectin fasting concentrations
Pacini G;
2010
Abstract
SUMMARY Objective In type-1 diabetes mellitus (T1DM), the release of many hormones, not only from beta-cells, but also from adipocytes (adipokines) may be altered. After successful pancreas-kidney-transplantation (PKTx), T1DM patients can revert to a non-diabetic metabolism, but it is unclear whether alterations of adipokines are still present after PKTx. Design, patients and measurements Concentrations of adipokines [visfatin, retinol-binding protein-4 (RBP-4), adiponectin, high-molecular-weight (HMW) adiponectin] were measured at fasting in 10 PKTx and in 19 T1DM. Non diabetic healthy controls (CON, n=9) and 6 non-diabetic patients after kidney transplantation (KTx) were examined as control groups. In PKTx, KTx and CON, indices of insulin sensitivity (OGIS) and beta-cell function (Adaptation Index) were calculated from 75g-oral glucose-tolerance-test (OGTT) data. Results Fasting serum visfatin (T1DM: 56+/-4mug/L, PKTx: 42+/-6mug/L, KTx: 39+/-3mug/L, CON: 40+/-3 mug/L) and RBP-4 (T1DM: 490+/-26mug/L, PKTx: 346+/-39mug/L, KTx: 401+/-13mug/L, CON: 359+/-36mug/L) were increased by 40% and 36% respectively (each p<0.03) in T1DM only. Levels were positively correlated with HbA1c in all subjects (visfatin: r=0.43, p<0.004; RBP-4: r=0.46, p<0.03). Fasting plasma adiponectin was 80% higher in T1DM and in PKTx (T1DM: 18+/-2mg/L, PKTx: 18+/-3mg/L, KTx: 12+/-3mg/L, CON: 10+/-1mg/L;p<0.04) and was positively correlated with diabetes duration (r=0.37, p<0.02). HMW/total adiponectin ratio was increased in T1DM (p<0.02). PKTx displayed a normoglycaemic metabolism, were as insulin sensitive as CON, but adaptation index was lower than in CON and KT (p<0.01). Conclusions T1DM after successful PKTx show normal fasting visfatin and RBP-4 levels and HMW-adiponectin/adiponectin-ratio, which are elevated in T1DM, whereas total adiponectin levels are similarly increased in T1DM and PKTx patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
