Boron neutron capture therapy (BNCT) is a binary radiation therapy used to treat malignant brain tumors. It is based on the nuclear reaction (B-10 + n(th) -> [B-11*]-> alpha + Li-7 + 2.79 MeV) that occurs when B-10 captures a thermal neutron to yield alpha particles and recoiling Li-7 nuclei, both responsible of tumour cells destruction by short range and high ionization energy release. The clinical success of the therapy depends on the Selective accumulation of the B-10 carriers in the tumour and on the high thermal neutron capture cross-section of B-10. Magnetic resonance imaging (MRI) methods provide the possibility of monitoring, through B-10 nuclei, the metabolic and physiological processes suitable to optimize the BNCT procedure. In this study, spatial distribution mapping of borocaptate (BSH) and 4-boronophenylalanine (BPA), the two boron carriers used in clinical trials, has been obtained. The BSH map in excised rat brain and the F-19-BPA image in vivo rat brain, representative of BPA spatial distribution, were reported. The BSH image was obtained by means of double resonance B-10-editing H-1-detection sequence, named M-Bend, exploiting the J-coupling interaction between B-10 and H-1 nuclei. Conversely, the BPA map was obtained by F-19-BPA using F-19-MRI. Both images were obtained Lit 7 T, in C6 glioma-bearing rat brain. Our results demonstrate the powerful of non conventional MRI techniques to optimize the BNCT procedure. (C) 2008 Elsevier Inc. All rights reserved.
B-10-editing H-1-detection and F-19 MRI strategies to optimize boron neutron capture therapy
Capuani S;
2008
Abstract
Boron neutron capture therapy (BNCT) is a binary radiation therapy used to treat malignant brain tumors. It is based on the nuclear reaction (B-10 + n(th) -> [B-11*]-> alpha + Li-7 + 2.79 MeV) that occurs when B-10 captures a thermal neutron to yield alpha particles and recoiling Li-7 nuclei, both responsible of tumour cells destruction by short range and high ionization energy release. The clinical success of the therapy depends on the Selective accumulation of the B-10 carriers in the tumour and on the high thermal neutron capture cross-section of B-10. Magnetic resonance imaging (MRI) methods provide the possibility of monitoring, through B-10 nuclei, the metabolic and physiological processes suitable to optimize the BNCT procedure. In this study, spatial distribution mapping of borocaptate (BSH) and 4-boronophenylalanine (BPA), the two boron carriers used in clinical trials, has been obtained. The BSH map in excised rat brain and the F-19-BPA image in vivo rat brain, representative of BPA spatial distribution, were reported. The BSH image was obtained by means of double resonance B-10-editing H-1-detection sequence, named M-Bend, exploiting the J-coupling interaction between B-10 and H-1 nuclei. Conversely, the BPA map was obtained by F-19-BPA using F-19-MRI. Both images were obtained Lit 7 T, in C6 glioma-bearing rat brain. Our results demonstrate the powerful of non conventional MRI techniques to optimize the BNCT procedure. (C) 2008 Elsevier Inc. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
