New enantiomerically enriched 1,4,5-piperazines and 1,4,5-dihydro-2H-pyrazines have beenp repared by reduction of the corresponding 2-oxo-piperazines. Selective reduction can be achieved by careful control of the reaction conditions using LiAlH4. Notably the two nitrogen atoms of the final compounds are orthogonally protected.
Synthesis of new polysubstituted piperazines and dihydro-2H-pyrazines by selective reduction of 2-oxo-piperazines
Reginato Gianna;Mordini Alessandro
2010
Abstract
New enantiomerically enriched 1,4,5-piperazines and 1,4,5-dihydro-2H-pyrazines have beenp repared by reduction of the corresponding 2-oxo-piperazines. Selective reduction can be achieved by careful control of the reaction conditions using LiAlH4. Notably the two nitrogen atoms of the final compounds are orthogonally protected.File in questo prodotto:
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