The presence of lithium increased the level of gamma-aminobutyric acid (Gaba) and inositol 1,4,5-triphosphate (IP3) in rice roots during 3 h of anoxia. The IP3 increase induced by Li+ was abolished by the phospholipase C inhibitor neomycin. The effect of Li+ on Gaba accumulation was inhibited by the presence of the calmodulin antagonist trifluoperazine. These findings are consistent with an inhibitory effect of Li+ on inositol monophosphatase which increased the IP3 level. This is a further confirm of the role of IP3 in the anaerobic signal transduction pathway.
Lithium alters phosphoinositide signaling in rice roots under anoxia
Reggiani R;
2002
Abstract
The presence of lithium increased the level of gamma-aminobutyric acid (Gaba) and inositol 1,4,5-triphosphate (IP3) in rice roots during 3 h of anoxia. The IP3 increase induced by Li+ was abolished by the phospholipase C inhibitor neomycin. The effect of Li+ on Gaba accumulation was inhibited by the presence of the calmodulin antagonist trifluoperazine. These findings are consistent with an inhibitory effect of Li+ on inositol monophosphatase which increased the IP3 level. This is a further confirm of the role of IP3 in the anaerobic signal transduction pathway.File in questo prodotto:
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