Six different racemates of the profen family were used as analytes in order to test the properties of chiral selectors of the three members of a new class of cyclodextrin derivatives called hemispherodextrins (HMs) in capillary electrophoresis. Besides experiments carried out to separate each enantiomeric pair one by one, other experiments were carried out on samples containing all the six enantiomeric pairs together. Electropherograms were obtained either by adding a single HM to BGE, or a binary mixture of HMs. The results obtained confirm the excellent properties of chiral selectivity of HMs, and furthermore show that these compounds can be used for achiral selection too. When mixing different HMs, a sort of complementary effect in chiral selectivity is observed, which, in our opinion, deserves further study.
The simultaneous separation of different enantiomeric pairs in capillary electrophoresis by mixing different hemispherodextrins, a very versatile class of receptors
2002
Abstract
Six different racemates of the profen family were used as analytes in order to test the properties of chiral selectors of the three members of a new class of cyclodextrin derivatives called hemispherodextrins (HMs) in capillary electrophoresis. Besides experiments carried out to separate each enantiomeric pair one by one, other experiments were carried out on samples containing all the six enantiomeric pairs together. Electropherograms were obtained either by adding a single HM to BGE, or a binary mixture of HMs. The results obtained confirm the excellent properties of chiral selectivity of HMs, and furthermore show that these compounds can be used for achiral selection too. When mixing different HMs, a sort of complementary effect in chiral selectivity is observed, which, in our opinion, deserves further study.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.