A new and more efficient route to the synthesis of branched PEG for protein conjugation, bearing a reporter dipeptide Met-bAla, is described, which allows better purification of the final product by ion exchange chromatography. The product has the combined advantages of an umbrella- like branched structure, which allows a better coverage of the protein surface, and the presence of the dipeptide Met-bAla which has been used to detect the position of PEGylation within the peptide sequence.
An improved procedure for the synthesis of branched polyethylene glycols (pegs) with the reporter dipeptide Met-bala for protein conjugation
2002
Abstract
A new and more efficient route to the synthesis of branched PEG for protein conjugation, bearing a reporter dipeptide Met-bAla, is described, which allows better purification of the final product by ion exchange chromatography. The product has the combined advantages of an umbrella- like branched structure, which allows a better coverage of the protein surface, and the presence of the dipeptide Met-bAla which has been used to detect the position of PEGylation within the peptide sequence.File in questo prodotto:
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