Asymmetric reduction of three different biphenyl alkyl ketones with a (R)- oxazaborolidine as catalyst was successfully carried out and the corresponding biphenyl alcohols were obtained in high yield and ee. High diastereoselectivity was achieved with C2-conformationally stable 3,3'-bis- (2-hydroxyethyl)-2,2',6,6'-tetramethoxybiphenyl and more detailed investigations evidenced a cooperative effect between stereoaxis and stereocentre.
Stereoselective aldol condensation of boron enolates to trans a, b-epoxy aldehydes
2002
Abstract
Asymmetric reduction of three different biphenyl alkyl ketones with a (R)- oxazaborolidine as catalyst was successfully carried out and the corresponding biphenyl alcohols were obtained in high yield and ee. High diastereoselectivity was achieved with C2-conformationally stable 3,3'-bis- (2-hydroxyethyl)-2,2',6,6'-tetramethoxybiphenyl and more detailed investigations evidenced a cooperative effect between stereoaxis and stereocentre.File in questo prodotto:
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