The Mediterranean tunicate Stolonica socialis contains a new class of powerful cytotoxic acetogenins, generically named stolonoxides. In this paper, which also details the isolation and chemical characterization of a minor component (3a) of the tunicate extract, we report the potent inhibitory activity (IC50<1 mM) of stolonoxides (1a and 3a) on mitochondrial electron-transfer. The compounds affect specifically the functionality of Complex II (succinate:ubiquinone oxidoreductase) and Complex III (ubiquinol:cytochrome C oxidoreductase) in mammalian cells, thereby causing a rapid collapse of the whole energetic metabolism. This result, that differs from the properties of similar known products (e.g. 6), reflects the molecular features of stolonoxides.
Novel inhibitors of mitochondrial respiratory chain: endoperoxides from the tunicate Stolonica socialis
Fontana A;Cimino G;
2001
Abstract
The Mediterranean tunicate Stolonica socialis contains a new class of powerful cytotoxic acetogenins, generically named stolonoxides. In this paper, which also details the isolation and chemical characterization of a minor component (3a) of the tunicate extract, we report the potent inhibitory activity (IC50<1 mM) of stolonoxides (1a and 3a) on mitochondrial electron-transfer. The compounds affect specifically the functionality of Complex II (succinate:ubiquinone oxidoreductase) and Complex III (ubiquinol:cytochrome C oxidoreductase) in mammalian cells, thereby causing a rapid collapse of the whole energetic metabolism. This result, that differs from the properties of similar known products (e.g. 6), reflects the molecular features of stolonoxides.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
