Asymmetric reduction of three different biphenyl alkyl ketones with a (R)- oxazaborolidine as catalyst was successfully carried out and the corresponding biphenyl alcohols were obtained in high yield and ee. High diastereoselectivity was achieved with C2-conformationally stable 3,3-bis- (2-hydroxyethyl)-2,2,6,6-tetramethoxybiphenyl and more detailed investigations evidenced a cooperative effect between stereoaxis and stereocentre.
Stereoselective oxazaborolidine-borane reduction of biphenyl alkyl ketons
Delogu G;Fabbri D;Patti A;Pedotti S
2002
Abstract
Asymmetric reduction of three different biphenyl alkyl ketones with a (R)- oxazaborolidine as catalyst was successfully carried out and the corresponding biphenyl alcohols were obtained in high yield and ee. High diastereoselectivity was achieved with C2-conformationally stable 3,3-bis- (2-hydroxyethyl)-2,2,6,6-tetramethoxybiphenyl and more detailed investigations evidenced a cooperative effect between stereoaxis and stereocentre.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
