Lipases from Candida antarctica and from Mucor miehei efficiently catalyze the enantioselective esterification of rac-1-(3-trifluoromethylphenyl)propan-2-ol. The obtained enantioforms are suitable to prepare both enantiomers of fenfluramine.
Effective enzymatic resolution of rac-1-(3-trifluoromethylphenyl)propan-2-ol, precursor of fenfluramine.
Nicola D'Antona;Giovanni Nicolosi
2002
Abstract
Lipases from Candida antarctica and from Mucor miehei efficiently catalyze the enantioselective esterification of rac-1-(3-trifluoromethylphenyl)propan-2-ol. The obtained enantioforms are suitable to prepare both enantiomers of fenfluramine.File in questo prodotto:
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