We present an in silico model that simulates the immune system responses to tumor cells in naive and vaccinated mice. We have demonstrated the ability of this model to accurately reproduce the experimental results. Motivation: In vivo experiments on HER-2/neu mice have shown the effectiveness of Triplex vaccine in protection of mice from mammary carcinoma. Full protection was conferred using Chronic (prophylactic) vaccination protocol while therapeutic vaccination was less ef cient. Our in silico model was able to closely reproduce the effects of various vaccination protocols. This model is the rst step towards the development of in silico experiments searching for optimal vaccination protocols. Results: In silico experiments carried out on two large statistical samples of virtual mice showed very good agreements with in vivo experiments for all experimental vaccination protocols. They also show, as supported by in vivo experiments, that the humoral response is fundamental in controlling the tumor growth and therefore suggest the selection and timing of experiments for measuring the activity of T cells.
Modeling and Simulation of Cancer Immunoprevention Vaccine
Castiglione F;
2005
Abstract
We present an in silico model that simulates the immune system responses to tumor cells in naive and vaccinated mice. We have demonstrated the ability of this model to accurately reproduce the experimental results. Motivation: In vivo experiments on HER-2/neu mice have shown the effectiveness of Triplex vaccine in protection of mice from mammary carcinoma. Full protection was conferred using Chronic (prophylactic) vaccination protocol while therapeutic vaccination was less ef cient. Our in silico model was able to closely reproduce the effects of various vaccination protocols. This model is the rst step towards the development of in silico experiments searching for optimal vaccination protocols. Results: In silico experiments carried out on two large statistical samples of virtual mice showed very good agreements with in vivo experiments for all experimental vaccination protocols. They also show, as supported by in vivo experiments, that the humoral response is fundamental in controlling the tumor growth and therefore suggest the selection and timing of experiments for measuring the activity of T cells.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
