he crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clin. relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.
Structural insight into the antibiotic action of telithromycin against resistant mutants.
Berisio Rita;
2003
Abstract
he crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clin. relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
